|
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Effect of TET1 regulating MGMT on chemotherapy resistance of oral squamous cell carcinoma stem cells.
|
28643947 |
2018 |
|
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Influence of MTHFR Genetic Background on p16 and MGMT Methylation in Oral Squamous Cell Cancer.
|
28353639 |
2017 |
|
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aberrant gene promoter methylation of E-cadherin, p16 <sup>INK4a</sup> , p14 <sup>ARF</sup> , and MGMT in Epstein-Barr virus-associated oral squamous cell carcinomas.
|
28573642 |
2017 |
|
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression profiles of MGMT, p16, and APC genes in tumor and matching surgical margin from patients with oral squamous cell carcinoma.
|
27494112 |
2016 |
|
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results showed two hypomethylated genes (CDKN2A and MGMT) and three hypermethylated genes (CDH13, RUNX3 and APC) in ACs compared with SCCs.
|
26862903 |
2016 |
|
Squamous cell carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
In lung cancer, P16INK4a and MGMT gene hypermethylation was observed in sputum years before clinical manifestation of the squamous cell carcinoma among smokers.
|
22359284 |
2012 |
|
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conclusions are as follows: (i) the epigenetic inactivation of genes is a common event in vulvar SCC and is also present in adjacent lesions, implying a possible precursor role for these alterations; (ii) MGMT and RASSF2A hypermethylation are present exclusively in vulvar SCC and LS associated with SCC, and absent from isolated LS; and (iii) TSP-1 hypermethylation is a bad prognosis factor in vulvar SCC.
|
20734389 |
2011 |
|
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In receiver-operating characteristic analysis, the three-gene combination (RAR-beta/Twist/MGMT) showed the best performance to distinguish HSIL/SCC from LCIS/negative samples.
|
19836067 |
2010 |
|
Squamous cell carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
We used pyrosequencing to evaluate global (using long interspersed nuclear element 1) and gene-specific (p16 and MGMT) methylation status in 47 SCCs and 40 adjacent autologous non-neoplastic skin samples in those with (n = 16) and without (n = 17) the MTHFR polymorphism.
|
20346029 |
2010 |
|
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We examined the promoter hypermethylation status of p16(INK4A) (p16), glutathione S-transferase pi (GSTP1), O(6)-methylguanine-DNA methyltransferase (MGMT), death-associated protein kinase 1 (DAPK1), RAS-association domain family 1, isoform A (RASSF1A), and E-cadherin (CDH1) genes in OSCC tumors.
|
20729138 |
2010 |
|
Squamous cell carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
More interestingly, MGMT hypermethylation in SCC and ADC was pronouncedly influenced by gender factor, not by smoking status.
|
19596925 |
2009 |
|
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Loss of expression of DNA repair enzyme MGMT in oral leukoplakia and early oral squamous cell carcinoma.A prognostic tool?
|
18973931 |
2009 |
|
Squamous cell carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
LHGDN |
Promoter methylation of TIMP3 and CDH1 predicts better outcome in head and neck squamous cell carcinoma treated by radiotherapy only.
|
19148529 |
2009 |
|
Squamous cell carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
MGMT promoter methylation in p53 mutation patterns had a different effect on squamous cell carcinomas (SCC) and adenocarcinomas (ADC).
|
18712569 |
2008 |
|
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Reduced expression of human DNA repair genes in esophageal squamous-cell carcinoma in china.
|
17479411 |
2007 |
|
Squamous cell carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Aberrant promoter hypermethylation of p16 and MGMT genes in oral squamous cell carcinomas and the surrounding normal mucosa.
|
16791592 |
2006 |
|
Squamous cell carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
LHGDN |
Aberrant promoter hypermethylation of p16 and MGMT genes in oral squamous cell carcinomas and the surrounding normal mucosa.
|
16791592 |
2006 |
|
Squamous cell carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequency of cancer-related gene methylation in SCCs was: CDH1 (95%), p16 (20%), p14 (15%), DAPK1 (15%), MGMT (15%), RB1 (5%), RASSF1 (5%), p15 (0%), PTEN (0%), PRDM2 (0%) and p53 (0%).
|
17034532 |
2006 |
|
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MGMT protein was expressed in 10% of non-neoplastic cervices, but significantly increased in SCC (42.5%) and adenocarcinoma (70.0%).
|
15785933 |
2005 |
|
Squamous cell carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Promoter hypermethylation and inactivation of O(6)-methylguanine-DNA methyltransferase in esophageal squamous cell carcinomas and its reactivation in cell lines.
|
15703815 |
2005 |
|
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
The methylation status of the MGMT gene was investigated by methylation-specific polymerase chain reaction (PCR) and expression status was investigated by immunohistochemistry in 70 cases of pulmonary squamous cell carcinoma (pulmonary SqCC), including 23 cases of the central type and 47 cases of the peripheral type, and in 53 cases of the peripheral type of pulmonary adenocarcinoma (AC).
|
15943786 |
2005 |
|
Squamous cell carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
The methylation status of the MGMT gene was investigated by methylation-specific polymerase chain reaction (PCR) and expression status was investigated by immunohistochemistry in 70 cases of pulmonary squamous cell carcinoma (pulmonary SqCC), including 23 cases of the central type and 47 cases of the peripheral type, and in 53 cases of the peripheral type of pulmonary adenocarcinoma (AC).
|
15943786 |
2005 |
|
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promoter hypermethylation profile of tumor-associated genes p16, p15, hMLH1, MGMT and E-cadherin in oral squamous cell carcinoma.
|
12672028 |
2003 |
|
Squamous cell carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Aberrant methylation in at least one gene was found in 63 of 75 (84%) NSCLCs. p16, RARbeta, DAP kinase, and MGMT methylation was similar in adenocarcinoma and SCC.
|
12473584 |
2002 |
|
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated promoter hypermethylation of six genes, p16, APC, HIC-1, death-associated protein kinase (DAPK), O(6)-methylguanine-DNA-methyltransferase (MGMT), and E-cadherin, in uterine cervical carcinoma from 53 patients including 31 cases of squamous cell carcinoma (SCC) and 22 cases of adenocarcinoma (AC).
|
11448914 |
2001 |