|
Colorectal Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Colorectal tumors and precursor lesions frequently display epigenetic inactivation of MGMT resulting from promoter hypermethylation, which is tightly associated with the occurrence of G:C to A:T transition mutations in the KRAS oncogene.
|
23929436 |
2013 |
|
Colorectal Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Then we used these assays for the analysis of MGMT and APC promoter methylation in a subset of archival formalin-fixed paraffin-embedded colorectal tumor specimens.
|
19179456 |
2009 |
|
Colorectal Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Recently, Herfarth et al. reported that a subset of colorectal tumors was characterized by a specific methylation pattern in the MGMT promoter associated with reduced MGMT expression.
|
20044616 |
2009 |
|
Colorectal Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
LHGDN |
Methylation of the MGMT and p16 genes in sporadic colorectal carcinoma and corresponding normal colonic mucosa.
|
18830187 |
2008 |
|
Colorectal Neoplasms
|
0.100 |
AlteredExpression
|
group |
LHGDN |
MGMT expression negative in surgical margin tissues indicates longer overall survival for colorectal tumor patients.
|
18028895 |
2008 |
|
Colorectal Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations.
|
18516290 |
2008 |
|
Colorectal Neoplasms
|
0.100 |
Biomarker
|
group |
LHGDN |
Comethylation of p16 and MGMT genes in colorectal carcinoma: correlation with clinicopathological features and prognostic value.
|
17451198 |
2007 |
|
Colorectal Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
LHGDN |
Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions.
|
17352030 |
2007 |
|
Colorectal Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer.
|
17621591 |
2007 |
|
Colorectal Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
LHGDN |
Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer.
|
16436636 |
2006 |
|
Colorectal Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Hypermethylation of the CpG island of MGMT gene was associated with loss of MGMT expression and K-ras G to A point mutation in colorectal tumor.
|
15800999 |
2005 |
|
Colorectal Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
LHGDN |
MGMT promoter methylation and field defect in sporadic colorectal cancer.
|
16174854 |
2005 |
|
Colorectal Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
LHGDN |
Hypermethylation of O6-methylguanine-DNA methyltransferase promoter may predict nonrecurrence after chemotherapy in colorectal cancer cases.
|
14614014 |
2003 |
|
Colorectal Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Alteration of O6-methylguanine-DNA methyltransferase in colorectal neoplasms in sporadic and familial adenomatous polyposis patients.
|
12720298 |
2003 |
|
Colorectal Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To study the relevance of defective MGMT function by aberrant methylation in relation to the presence of p53 mutations, we studied 314 colorectal tumors for MGMT promoter hypermethylation and p53 mutational spectrum.
|
11406538 |
2001 |
|
Colorectal Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We conclude that a subset of colorectal tumors is characterized by a specific methylation pattern in the MGMT promoter associated with reduced MGMT expression.
|
10078936 |
1999 |