Neuroectodermal Tumor, Primitive
|
0.100 |
Biomarker
|
disease |
BEFREE |
Histologically, the PNET-like component showed morphological features akin to anaplastic medulloblastoma highlighted by widespread immunoreactivity for βIII-tubulin (TUBB3) and nonphosphorylated neurofilament protein, and to a lesser degree, Neu-N, synaptophysin, and CD99, whereas the gliomatous component was demarcated by glial fibrillary acidic protein (GFAP) labeling.
|
27781423 |
2017 |
Neuroectodermal Tumor, Primitive
|
0.100 |
Biomarker
|
disease |
BEFREE |
We obtained the final diagnosis of ES/PNET by immunohistochemical molecular study with positive staining for the MIC2 gene product (CD99) and a Ewing sarcoma breakpoint region 1 (EWSR1) gene rearrangement.
|
24158076 |
2013 |
Neuroectodermal Tumor, Primitive
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Herein, we describe a DSRCT in the maxilla of a young man, who was initially diagnosed with a primitive neuroectodermal tumor (PNET), based on histopathological appearance of a round cell tumor, with MIC2 and -FLI-1 positivity, on immunohistochemistry (IHC).
|
20739766 |
2010 |
Neuroectodermal Tumor, Primitive
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, one PNET originating in the intracranial dura mater was positive for both MIC2 and EWS-FLI1 fusion gene.
|
11304041 |
2001 |
Neuroectodermal Tumor, Primitive
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MIC2 is characteristically expressed in lymphoblastic lesions and Ewing's/primitive neuroectodermal tumor sarcomas.
|
10786814 |
2000 |
Neuroectodermal Tumor, Primitive
|
0.100 |
Biomarker
|
disease |
BEFREE |
Also, it should be remembered that cytoplasmic staining for MIC2 protein may occur in sarcomas other than PNET/ES.
|
10563198 |
1999 |
Neuroectodermal Tumor, Primitive
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Based on the cytogenetic results and on the immunohistological investigation of MIC 2 expression, Ewing's sarcoma is suggested to be related closely to primitive neuroectodermal tumour.
|
9072004 |
1997 |
Neuroectodermal Tumor, Primitive
|
0.100 |
Biomarker
|
disease |
BEFREE |
Based on the cytogenetic analysis, Ewing's sarcoma is related closely with PNET as shown by MIC2-protein reactivity.
|
9103213 |
1997 |
Neuroectodermal Tumor, Primitive
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunohistochemically, the tumor cells stained strongly positive for HBA71(p30/32MIC2), a surface glycoprotein specific to PNET and Ewing's sarcoma.
|
8726854 |
1996 |
Neuroectodermal Tumor, Primitive
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We conclude that among the SRCTs, MIC2 expression is not limited to Ewing's sarcoma and primitive neuroectodermal tumors, but also shows strong and reliable expression in lymphoblastic lymphomas and related leukemias.
|
8163272 |
1994 |