Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
N-myc or Ascl1 activates endogenous INSM1 expression in lung cancer cells.
|
29501727 |
2018 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that SCNN1A/αENaC is a direct transcriptional target of the neuroendocrine lung cancer lineage oncogene ASCL1 that can be pharmacologically targeted with antitumor effects.
|
29413762 |
2018 |
Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
ASCL1 mRNA expression was found almost exclusively in smokers with AD, in contrast to non-smokers and other lung cancer subtypes.
|
24037524 |
2014 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Analysis of downstream targets of ASCL1 represents an important advance in the development of targeted therapy for the neuroendocrine class of lung cancers, providing a significant step forward in the understanding and therapeutic targeting of the molecular vulnerabilities of neuroendocrine lung cancer.
|
25267614 |
2014 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of nestin and achaete-scute homolog 1 (ASH1) was studied in 21 lung cancer cell lines.
|
23706418 |
2013 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Achaete-scute homologue-1 (ASH1) stimulates migration of lung cancer cells through Cdk5/p35 pathway.
|
22696682 |
2012 |
Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We examined human ASH1 (hASH1) expression across a comprehensive panel of human lung cancer cell lines, primary human lung tumors and normal fetal and post-natal lungs.
|
21684625 |
2012 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Loss- and gain-of-function experiments in human bronchial epithelial and lung carcinoma cell lines revealed that Ascl1, MMP-7 and MGMT are able to protect cells from the tobacco-specific nitrosamine NNK-induced DNA damage and the alkylating agent cisplatin-induced apoptosis.
|
23300791 |
2012 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
miR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dependent manner in lung cancer.
|
21856745 |
2011 |
Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data indicate a specific role for ASCL1 in regulating the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus.
|
20124469 |
2010 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Knockdown of hASH1 gene in human lung cancer cells in vitro suppressed growth by increasing apoptosis.
|
17507989 |
2007 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study therefore suggests that ASH1 plays a crucial role in lung cancer development and may be an effective therapeutic target in lung cancers with neuroendocrine features.
|
16322211 |
2005 |
Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that GFI1, as with ASH1, is expressed in neuroendocrine lung cancer cell lines and that GFI1 in lung cancer cell lines functions as a DNA-binding transcriptional repressor protein.
|
15466176 |
2004 |
Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In small cell lung cancer (SCLC), the most lethal form of lung cancer, the gene is highly expressed and the expression of HASH1 correlates with NE features found in SCLCs.
|
11948117 |
2002 |
Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression.
|
9144241 |
1997 |