|
Squamous cell carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined the influence of MLH1 c.-93G>A, MSH2 c.211 + 9C>G, MSH3 c.3133G>A and EXO1 c.1765G>A polymorphisms, involved in DNA mismatch repair (MMR), on head and neck (HN) squamous cell carcinoma (SCC) risk and prognosis.
|
25598504 |
2015 |
|
Squamous cell carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The hMLH1 -93G>A promoter polymorphism is associates with outcomes in oral squamous cell carcinoma patients.
|
25047469 |
2014 |
|
Squamous cell carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
The frequency of promoter hypermethylation found on these DNA repair genes was elevated, with a higher prevalence of methylation of MLH1 gene in 72% of squamous cell carcinoma.
|
24360395 |
2014 |
|
Squamous cell carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Statistically significant increased frequency of MLH1 allelic loss in squamous cell carcinoma (SCC) versus non-squamous cell carcinoma (non-SCC) was observed (p = 0.01).
|
23504373 |
2013 |
|
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
hMSH2 and hMLH1 gene expression patterns differ between lung adenocarcinoma and squamous cell carcinoma: correlation with patient survival and response to adjuvant chemotherapy treatment.
|
22865300 |
2013 |
|
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Relation between its altered expression linked to microsatellite instability has also been observed in oral leukoplakias (OL) and squamous cell carcinomas pointing to a possible role of hMLH1 in oral carcinogenesis.
|
20969633 |
2011 |
|
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
(i) Immunohistochemical staining was used to assess expression of the MMR proteins MSH2 and MLH1 in cutaneous SCCs from OTRs on azathioprine and from immunocompetent patients.
|
19818066 |
2010 |
|
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Immunoexpression of hMSH2 and hMLH1 in oral squamous cell carcinoma and its relationship to histological grades of malignancy.
|
18331286 |
2008 |
|
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Low hMLH1 expression prior to definitive chemoradiotherapy predicts poor prognosis in esophageal squamous cell carcinoma.
|
18053639 |
2008 |
|
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Significance and mechanism of microsatellite instability in laryngeal squamous cell carcinoma.
|
17711772 |
2007 |
|
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Inactivation of human mutL homolog 1 and mutS homolog 2 genes in head and neck squamous cell carcinoma tumors and leukoplakia samples by promoter hypermethylation and its relation with microsatellite instability phenotype.
|
17219447 |
2007 |
|
Squamous cell carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study was to assess hMSH2 and hMLH1 gene mutations, microsatellite DNA alterations, and investigate the association between these alterations and clinicopathological features of oral squamous cell carcinomas (SCC) in a sample of Thai patients.
|
16918138 |
2006 |
|
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Correlation among loss of heterozygosity, promoter methylation and protein expression of MLH1 in larynx cancer.
|
14767526 |
2004 |
|
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Impairment of MLH1 and CDKN2A in oncogenesis of laryngeal cancer.
|
15083191 |
2004 |
|
Squamous cell carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
LHGDN |
Promoter hypermethylation and inactivation of hMLH1, a DNA mismatch repair gene, in head and neck squamous cell carcinoma.
|
12605036 |
2003 |
|
Squamous cell carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
LHGDN |
To test whether a subset of esophageal squamous cell carcinomas (SCC) develop through a deficiency in DNA mismatch repair, we examined microsatellite instability (MSI) using 11 microsatellite markers including BAT-26, hMLH1 protein expression by immunohistochemistry, and methylation status of the hMLH1 promoter by methylation-specific polymerase chain reaction (MSP). p53 mutations were also investigated.
|
12713560 |
2003 |
|
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Reduced MLH1 expression after chemotherapy is an indicator for poor prognosis in esophageal cancers.
|
14555508 |
2003 |
|
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To test whether a subset of esophageal squamous cell carcinomas (SCC) develop through a deficiency in DNA mismatch repair, we examined microsatellite instability (MSI) using 11 microsatellite markers including BAT-26, hMLH1 protein expression by immunohistochemistry, and methylation status of the hMLH1 promoter by methylation-specific polymerase chain reaction (MSP). p53 mutations were also investigated.
|
12713560 |
2003 |
|
Squamous cell carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest: i) that MSI plays a role in the pathogenesis of Korean oral cancers, squamous cell carcinomas (4%) and salivary gland tumors (20%); ii) that genetic alteration or hypermethylation of the hMLH1 gene may be the principal inactivating mechanism in Korean oral cancer with MSI; and iii) that inactivation of the p53 gene by either mutation or HPV infection is frequent in Korean squamous cell carcinomas (26%) and salivary gland tumors (40%).
|
12118324 |
2002 |
|
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study 28 skin lesions from 17 patients (20 sebaceous gland tumors, 4 sebaceous hyperplasias, 3 keratoacanthomas, and 1 squamous cell carcinoma) were tested immunohistochemically with antibodies against MSH2 and MLH1.
|
11859205 |
2002 |
|
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mlh1 immunoreactivity was observed in 10 of 14 (71.4%) NISCCs and in 8 of 23 (34.8%) ISCCs (P < 0.04).
|
10999751 |
2000 |