MLH1, mutL homolog 1, 4292

N. diseases: 526; N. variants: 757
Disease: Acute lymphocytic leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia 		0.030 Biomarker disease BEFREE Therefore, we have analysed alternative splicing of hMLH1 in a cohort of children with ALL. 19767099 2010
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia 		0.030 PosttranslationalModification disease BEFREE MLH1 promoter was not methylated in either of the twelve peripheral blood samples from normal individuals or ALL samples. 15944788 2005
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia 		0.030 GeneticVariation disease BEFREE However, when the MLH1 genotypes were combined with genotypes previously shown to influence ALL susceptibility, we found that the MLH1 variant Val-219 further increases the risk of GSTM1 null and CYP1A1*2A genotypes [combined odds ratio (OR) = 6.0, P = 0.002] as well as that of CYP2E1*5 (OR = 15.8, P = 0.001). 14510941 2003