MLH1, mutL homolog 1, 4292

N. diseases: 526; N. variants: 757
Disease: Adenomatous Polyps ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0206677
Disease: Adenomatous Polyps
Adenomatous Polyps 		0.020 Biomarker disease BEFREE We investigated the methylation status in the promoter regions of the CDKN2A/p16, hMLH1, and MGMT genes in human non-neoplastic rectal mucosa and evaluated whether these methylation markers may predict the presence of adenomatous polyps in the colon. 16820927 2006
CUI: C0206677
Disease: Adenomatous Polyps
Adenomatous Polyps 		0.020 AlteredExpression disease BEFREE Hypermethylation of the promoter of hMLH1, consequent loss of hMLH1 expression, and MSI are at the basis of approximately 25% of adenomatous polyps developed in subjects with a SFDR affected by colorectal cancer. 12591727 2003