Carcinoma of lung
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
These results suggest that chromate exposure might induce MLH1 hypermethylation in LC as a mechanism of chromate-induced carcinogenesis.
|
31579968 |
2020 |
Carcinoma of lung
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The characterization and numeration of CTCs based on the expression of MLH1 and mesenchymal markers may be a convenient approach for predicting treatment response and prognosis in lung cancer.
|
31232917 |
2019 |
Carcinoma of lung
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We detected the epidermal growth factor receptor L858R, MSH2 R929* and telomerase reverse transcriptase amplification in the lung cancer specimen; CDH1 c.1320+1G>T mutation in the gastric cancer (GC) specimen; and MLH1 c.1896+5G>A germline mutation in the lung and GC specimens by 450 cancer-related gene mutations detection using next-generation sequencing technology.
|
31207149 |
2019 |
Carcinoma of lung
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The MLH1 protein expression was evaluated by immunohistochemistry on tissue microarrays including 121 primary CRC and 90 lung cancer patient samples.
|
28214209 |
2017 |
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
MutL homologue 1 (MLH1) is the direct target of miR-148b which is required for the regulatory role of miR-148b in radioresistance. miR-148b mimic sensitized A549 xenografts to irradiation in vivo Our study demonstrated that miR-148b regulates radioresistance of lung cancer cells by modulating MLH1 expression level. miR-148b may represent a new therapeutic target for the intervention of lung cancer.
|
26759383 |
2016 |
Carcinoma of lung
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We unravelled a potential for increased risk of lung cancer development in the hMLH1 (rs1800734) AA genotype in the recessive model.
|
26987333 |
2016 |
Carcinoma of lung
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In the present case-control study, we investigated the promoter polymorphisms of selected mismatch repair genes: hMLH1 (rs1800734) and hMSH2 (rs2303425), and the risk they present regarding the development of lung cancer in the Slovak population.
|
25252909 |
2015 |
Carcinoma of lung
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Consistently, the haplotype of MLH1 with one -93G risk allele was associated with the risk of lung cancer compared with the AA haplotype among the never-smoking group.
|
21093954 |
2011 |
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
RGD |
Molecular analysis of DNA repair gene methylation and protein expression during chemical-induced rat lung carcinogenesis.
|
21530494 |
2011 |
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
Methylation of multiple genes (particularly hMLH1, p16, and APC genes) had experienced more than 15 yr of chromate exposure in chromate lung cancer (MI: <15 yr; 0.19, ≥ 15 yr, 0.42).
|
21229606 |
2011 |
Carcinoma of lung
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
This is the first case-control study to show a significant association between the hMLH1-93G-->A polymorphism and the susceptibility to and prognosis of lung cancer.
|
19956916 |
2010 |
Carcinoma of lung
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
These findings indicate that the hMLH1 rs1799977 polymorphism may contribute to the etiology of early-onset lung cancer as well as some specific subtype of lung cancer.
|
17870204 |
2008 |
Carcinoma of lung
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
However, microsatellite instability and loss of MLH1 expression was rare, suggesting that MLH1 promoter methylation does not usually lead to gene silencing in lung cancer.
|
18594535 |
2008 |
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
Promoter hypermethylation is the predominant mechanism in hMLH1 and hMSH2 deregulation and is a poor prognostic factor in nonsmoking lung cancer.
|
16061855 |
2005 |
Carcinoma of lung
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The genetic instability of chromate lung cancer is due to the repression of hMLH1 protein.
|
15605365 |
2005 |
Carcinoma of lung
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association between the -93G-->A polymorphism in the hMLH1 gene and the risk of lung cancer in a Korean population.
|
15382050 |
2004 |