|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Mixed lineage kinase 3 (MLK3), a MAP3K member has been envisioned as a viable drug target in cancer, yet its detailed function and signaling is not fully elucidated.
|
30664689 |
2019 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Involvement of mixed lineage kinase 3 in cancer.
|
23627838 |
2013 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Involvement of mixed lineage kinase 3 in cancer.
|
23627838 |
2013 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Here we investigated the effect of MLK3 and its signaling to MAPKs in the acquisition of malignancy in breast cancer.
|
20514022 |
2010 |
|
Malignant Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
In conclusion, we have demonstrated for the first time the presence of MLK3 mutations in cancer and its association to mismatch repair deficiency.
|
19955118 |
2010 |
|
Primary malignant neoplasm
|
0.040 |
GeneticVariation
|
group |
BEFREE |
In conclusion, we have demonstrated for the first time the presence of MLK3 mutations in cancer and its association to mismatch repair deficiency.
|
19955118 |
2010 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Here we investigated the effect of MLK3 and its signaling to MAPKs in the acquisition of malignancy in breast cancer.
|
20514022 |
2010 |
|
Oestrogen receptor positive breast cancer
|
0.030 |
Biomarker
|
disease |
BEFREE |
Therefore coordinated transcriptional and post-translational repression of pro-apoptotic MLK3 probably is one of the mechanisms by which ER+ breast cancer cells proliferate and survive.
|
28388540 |
2017 |
|
Oestrogen receptor positive breast cancer
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Here we report that in non-metastatic, estrogen receptor-positive breast cancer (ER+ BC) cells, induced MLK3 expression robustly upregulates the oncogenic transcription factor, FOS-related antigen-1 (FRA-1), which is accompanied by elevation of matrix metalloproteinases (MMPs), MMP-1 and MMP-9.
|
28604765 |
2017 |
|
Oestrogen receptor positive breast cancer
|
0.030 |
Biomarker
|
disease |
BEFREE |
Estrogen suppresses MLK3-mediated apoptosis sensitivity in ER+ breast cancer cells.
|
20145118 |
2010 |
|
Delirium, Dementia, Amnestic, Cognitive Disorders
|
0.020 |
Biomarker
|
group |
BEFREE |
Anthocyanins attenuate neuroinflammation through the suppression of MLK3 activation in a mouse model of perioperative neurocognitive disorders.
|
31654642 |
2020 |
|
Neurocognitive Disorders
|
0.020 |
Biomarker
|
group |
BEFREE |
Anthocyanins attenuate neuroinflammation through the suppression of MLK3 activation in a mouse model of perioperative neurocognitive disorders.
|
31654642 |
2020 |
|
Malignant neoplasm of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that mammalian PAK1 does not act as a MAP4K and MLK3-induced direct activation of PAK1 plays a key role in breast cancer tumorigenesis.
|
30664689 |
2019 |
|
Cerebral Infarction
|
0.020 |
Biomarker
|
disease |
BEFREE |
The potential role of HO-1 in regulating the MLK3-MKK7-JNK3 module scaffolded by JIP1 during cerebral ischemia/reperfusion in rats.
|
30412737 |
2019 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that mammalian PAK1 does not act as a MAP4K and MLK3-induced direct activation of PAK1 plays a key role in breast cancer tumorigenesis.
|
30664689 |
2019 |
|
Malignant tumor of colon
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, S705A-S758A-FLAG-MLK3 demonstrated decreased oxidative-stress induced colon cancer cell invasion, but increased interaction with GST-B-Raf as compared with wild-type-FLAG-MLK3 in H<sub>2</sub>O<sub>2</sub>-treated cells.
|
29084209 |
2018 |
|
Colorectal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In human colorectal carcinoma (HCT116) cells treated with H<sub>2</sub>O<sub>2</sub>, extracellular signal-regulated kinases 1 and 2 (ERK1/2) were activated and MLK3 exhibited reduced electrophoretic mobility (shift) in sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), which was eliminated by phosphatase treatment.
|
29084209 |
2018 |
|
Colon Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, S705A-S758A-FLAG-MLK3 demonstrated decreased oxidative-stress induced colon cancer cell invasion, but increased interaction with GST-B-Raf as compared with wild-type-FLAG-MLK3 in H<sub>2</sub>O<sub>2</sub>-treated cells.
|
29084209 |
2018 |
|
Brain Ischemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Based on the facts that MLK3 is one client protein of HSP90 and MLK3 pathway induces FasL expression in ischemic brain injury, our study suggests one of the mechanisms of neuroprotection against brain ischemia from GA.
|
28522336 |
2017 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Mixed-lineage kinase 3 (MLK3), a mitogen-activated protein kinase kinase kinase (MAP3K), has critical roles in metastasis of triple-negative breast cancer (TNBC), in part by regulating paxillin phosphorylation and focal adhesion turnover.
|
28604765 |
2017 |
|
Mammary Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Publicly available data and in situ hybridization of human breast tumors showed significant down regulation of MLK3 transcripts in ER+ tumors.
|
28388540 |
2017 |
|
estrogen receptor-negative breast cancer
|
0.020 |
Biomarker
|
disease |
BEFREE |
Therefore coordinated transcriptional and post-translational repression of pro-apoptotic MLK3 probably is one of the mechanisms by which ER+ breast cancer cells proliferate and survive.
|
28388540 |
2017 |
|
Colorectal Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The results provide an overall view of the expression profile associated with mutant MLK3, and they support the functional role of mutant MLK3 by showing a deregulation of several signaling pathways known to play important roles in the development and progression of colorectal cancer.
|
24628919 |
2014 |
|
Malignant neoplasm of gastrointestinal tract
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
MLK3 gene mutations were described to occur in about 20% of microsatellite unstable gastrointestinal cancers and to harbor oncogenic activity.
|
24628919 |
2014 |
|
Delirium, Dementia, Amnestic, Cognitive Disorders
|
0.020 |
Biomarker
|
group |
BEFREE |
MLK3 activation is associated with many of the pathologic hallmarks of HAND (Bodner et al., 2002, 2004; Sui et al., 2006) and therefore represents a prime target for adjunctive therapy based on small-molecule kinase inhibition.
|
23761895 |
2013 |