|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The MLL gene is frequently rearranged in leukemias, and MLL chimeric proteins generated by chromosomal translocations play crucial roles in leukemogenesis.
|
11681416 |
2001 |
|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We conclude that concentrations of E2 and 4-OH-E2 that may occur during pregnancy, or during use of oral contraceptives, can cause aberrations of the MLL gene and could thus be a factor in the early events of leukemogenesis occurring in utero.
|
19264358 |
2009 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
MLL-fusion proteins, AF9 and ENL, play an essential role in the recruitment of DOT1L and the H3K79 hypermethylation of MLL target genes, which is pivotal for leukemogenesis.
|
30258537 |
2018 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that the basis for the leukemogenesis of t(11; 22)-AML is the inability of p300 to regulate cell-cycle and cell differentiation after fusion with MLL.
|
9389684 |
1997 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
SET domain-containing proteins such as MLL1 play a critical role in leukemogenesis, while others such as SETD2 may function as a tumor suppressor in breast cancer and renal cell carcinoma.
|
23065515 |
2013 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This insertion mechanism precludes the genomic recombination of AF4-MLL and supports the crucial role played by MLL-AF4 in leukemogenesis.
|
11368362 |
2001 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Therefore, we postulate that the inability of C/EBPα and GATA-1 to down-regulate DACH1 expression induced by MLL-AF9 during myeloid differentiation may contribute to t(9;11) leukemogenesis.
|
22902925 |
2012 |
|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
She provides an overview of leukemias that are common in pediatric malignancies but rarely observed in adults, including the TEL-AML1 (ETV6-RUNX1) fusion associated with pediatric B-cell ALL, the OTT-MAL fusion associated with infant megakaryoblastic leukemia, PTPN11 mutations in juvenile myelomonocytic leukemia, and MLL fusion genes in leukemogenesis, among others.
|
15561678 |
2004 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the spectrum of MLL translocation partners in adult T-ALL much more resembles that of AML than that of BCP ALL and thus the mechanisms by which MLL contributes to leukemogenesis in adult T-ALL appear to differ from those in BCP ALL.
|
22927255 |
2012 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This observation suggests that the N-terminal portion of MLL gene is critical for leukemogenesis in translocations involving band 11q23.
|
7833468 |
1995 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The identification and validation of consistent changes of gene expression in human and murine MLL rearrangement leukemias provide important insights into the genetic base for MLL-associated leukemogenesis.
|
19155294 |
2009 |
|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Typically, the breakpoints are upstream of the zinc-finger region of MLL, and deletion of this region can accompany translocation, supporting the der(11) chromosome as the important component in leukemogenesis.
|
8378328 |
1993 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data suggest that only one form of MLL fusion gene is implicated in leukemogenesis in our case to t(1;11;4).
|
10700861 |
2000 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, a mouse model of MLL-AF9-driven leukemogenesis was used to study the role of Baf200 in malignant hematopoiesis.
|
29482581 |
2018 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The role of MLL in leukemogenesis has previously been demonstrated, but its role in the development of other tumors or its significance in the chemoresistance process remains to be elucidated.
|
11135430 |
2001 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results show that not only MLL rearrangements, but also other molecular abnormalities occur before birth and may contribute to leukemogenesis.
|
16261608 |
2006 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MLL(DNMT1 CXXC)-AF9 shows robust in vitro colony forming activity and in vivo leukemogenesis, similar to MLL-AF9.
|
23990460 |
2013 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
AF4 antibodies should be useful for further elucidation of the function of AF4 in normal cellular physiology, as well as the function of MLL-AF4 in leukemogenesis.
|
9808577 |
1998 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis.
|
10861294 |
2000 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Aberrant fusion proteins involving the MLL histone methyltransferase (HMT) lead to recruitment of DOT1L, to a multi-protein complex resulting in aberrant methylation of histone H3 lysine 79 at MLL target genes, and ultimately enhanced expression of critical genes for hematopoietic differentiation, including HOXA9 and MEIS1, and as such defines the established mechanism for leukemogenesis in MLL-rearrangement (MLL-r) leukemias.
|
28229434 |
2017 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using an in vivo gene targeting approach, we demonstrate that Rac2, but not Rac1, is critical to the initiation of acute myeloid leukemia in a retroviral expression model of MLL-AF9 leukemogenesis.
|
21940819 |
2011 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Partial duplication of ALL-1, in which a portion of a putative protooncogene is fused with itself, represents an additional genetic mechanism for leukemogenesis.
|
8016145 |
1994 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conditional deletion of <i>Mof</i> in a mouse model of <i>MLL-AF9</i>-driven leukemogenesis reduced tumor burden and prolonged host survival.
|
28202522 |
2017 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data reveal a molecular dependency on MLL1 function in NUP98-fusion-driven leukemogenesis.
|
27889185 |
2016 |
|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, a single chromosomal rearrangement resulting in formation of the MLL-MLLT3 fusion gene and haplo-insufficiency of FLJ10374 may have cooperated to promote leukemogenesis in AML with t(9;11;19).
|
16450356 |
2006 |