|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Typically, the breakpoints are upstream of the zinc-finger region of MLL, and deletion of this region can accompany translocation, supporting the der(11) chromosome as the important component in leukemogenesis.
|
8378328 |
1993 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The composition of the complete MLL-AF4 fusion product argues that it may act through either a gain-of-function or a dominant negative mechanism in leukemogenesis.
|
7689231 |
1993 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Partial duplication of ALL-1, in which a portion of a putative protooncogene is fused with itself, represents an additional genetic mechanism for leukemogenesis.
|
8016145 |
1994 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The characterization of the normal functions of ELL as well as its altered function when fused to MLL will be critical to further our understanding of the mechanisms of leukemogenesis.
|
7991593 |
1994 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This observation suggests that the N-terminal portion of MLL gene is critical for leukemogenesis in translocations involving band 11q23.
|
7833468 |
1995 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that the N-terminal portion common to various MLL-chimeric products plays an important role in leukemogenesis.
|
8934541 |
1996 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that the basis for the leukemogenesis of t(11; 22)-AML is the inability of p300 to regulate cell-cycle and cell differentiation after fusion with MLL.
|
9389684 |
1997 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
CBP is the first partner gene of MLL containing well defined structural and functional motifs that provide unique insights into the potential mechanisms by which these translocations contribute to leukemogenesis.
|
9238046 |
1997 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that SJT of ABL and/or CD3 (MLL) genes is associated with the leukemogenesis of secondary leukemia.
|
9002963 |
1997 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We previously showed that the N-terminal portion common to various chimeric MLL products, as well as to MLL-LTG9 and MLL-LTG19, localizes in the nuclei, and therefore suggested that it might play an important role in leukemogenesis.
|
9349501 |
1997 |
|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Partial duplication of the MLL gene is a recently characterized novel genetic mechanism for leukemogenesis.
|
9242213 |
1997 |
|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The leukemogenesis by the t(11;19)(q23;p13.1) translocation may have resulted from the alteration of transcription regulation induced by the MLL/MEN fusion protein and/or the truncated MLL protein.
|
9277049 |
1997 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
AF4 antibodies should be useful for further elucidation of the function of AF4 in normal cellular physiology, as well as the function of MLL-AF4 in leukemogenesis.
|
9808577 |
1998 |
|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The clinical observation in this case supports the notion that leukemic transformation involves multiple cytogenetic evolutionary progresses, and that MLL gene rearrangement corresponds to the final step of leukemogenesis.
|
9594441 |
1998 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that the ABI-1 gene plays a role in leukemogenesis by translocating to MLL.
|
9694699 |
1998 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This is the first report of amplification of the MLL gene which may be an additional mechanism of leukemogenesis or disease progression.
|
9665199 |
1998 |
|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The MLL gene located on chromosome 11q23 and its translocation to the AF-4 gene located on chromosome 4q21 play a pivotal role in leukemogenesis in infancy.
|
9737688 |
1998 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To clarify the role of the multiple lineage leukemia gene-leukemia translocation gene of chromosome 19 (MLL-LTG19) protein in leukemogenesis, we synthesized antisense oligodeoxyribonucleotide (ODN) against the fused region of the MLL-LTG19 chimeric transcript and treated KOCL33 cells carrying the t(11;19) translocation with antisense ODN.
|
9731482 |
1998 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This type of MLL rearrangement may be transcribed into an mRNA species that is capable of encoding a partially duplicated protein associated with leukemogenesis.
|
9790509 |
1998 |
|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results show that LOH at the MLL gene locus is a common event during leukemogenesis.
|
10381524 |
1999 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The role of the many MLL fusion proteins in leukemogenesis is not yet understood.
|
10394590 |
1999 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data suggest that only one form of MLL fusion gene is implicated in leukemogenesis in our case to t(1;11;4).
|
10700861 |
2000 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis.
|
10861294 |
2000 |
|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Common genetic aberrations responsible for lymphomagenesis are deletions of 6q, loss of p53, and amplification of the 3q27 and the MLL gene regions.(Blood.2000;95:1180-1187)
|
10666188 |
2000 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The significance of MLL amplification and the mechanisms by which it could play a role in leukemogenesis and/or disease progression remain to be elucidated.
|
10918392 |
2000 |