|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using a mouse model of human acute myeloid leukemia (AML) induced by the MLL-AF9 oncogene, we demonstrate that colony-forming cells (CFCs) in the bone marrow and spleen of leukemic mice are also leukemia stem cells (LSCs).
|
17045204 |
2006 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Venetoclax responses of pediatric ALL xenografts reveal sensitivity of MLL-rearranged leukemia.
|
27343252 |
2016 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rearrangements in MLL (MLL-r) are common within very young children with leukemia and affect the prognosis and treatment.
|
21444110 |
2011 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The frequency and clinical correlations of MLL gene amplification in leukemia will need careful follow-up, since the frequently cryptic amplification described in these cases may not generally provoke confirmatory FISH studies.
|
16026782 |
2005 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There is an urgent need for the development of less toxic, more selective and targeted therapies for infants with leukemia characterized by translocation of the mixed lineage leukemia (MLL) gene.
|
27317766 |
2016 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This view is challenged by a recent observation in a case of leukemia with a complex translocation that results in MLL being fused in-frame to two different partner genes.
|
10700861 |
2000 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We applied our methods to five cancerous gene expression datasets: leukemia (acute lymphoblastic leukemia [ALL] vs. acute myeloid leukemia [AML]), lung cancer, prostate cancer, breast cancer, and leukemia (ALL vs. mixed-lineage leukemia [MLL] vs. AML).
|
19874631 |
2009 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The oncogenic role of MLL-AF4 is documented but the significance of the reciprocal product - AF4-MLL in leukemia is less clear.
|
20869771 |
2011 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Harnessing the hidden antitumor power of the MLL-AF4 oncogene to fight leukemia.
|
24735921 |
2014 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The pathways by which oncogenes, such as MLL-AF9, initiate transformation and leukemia in humans and mice are incompletely defined.
|
18455126 |
2008 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies on MLL and MLL leukemia have greatly advanced our knowledge concerning the normal function of MLL and its deregulation in leukemogenesis.
|
19729989 |
2009 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The developmental stage of the hematopoietic niche regulates lineage in <i>MLL-</i>rearranged leukemia.
|
30728174 |
2019 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
EPZ-5676 is therefore a potential treatment of MLL-rearranged leukemia and is under clinical investigation.
|
23801631 |
2013 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rare congenital forms of lymphoid or myeloid leukemia, manifested at birth or during the first month of life, carry a dismal prognosis, especially when a MLL/11q23 rearrangement is present; such cases should be carefully distinguished by chromosomal/molecular analysis and cell culture techniques from transient myeloproliferative disorders which require only supportive care but close follow-up for subsequent development of leukemia.
|
7769837 |
1995 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further elaboration of the biology of MLL gene-associated leukemia should lead to novel and specific therapeutic strategies.
|
16105754 |
2005 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
To address the impact of cellular origin on acute myeloid leukemia (AML), we generated an inducible transgenic mouse model for MLL-AF9-driven leukemia.
|
27344946 |
2016 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MLL rearrangements occurring in leukemia include MLL fusion genes, partial tandem duplications of MLL and MLL amplification.
|
15464450 |
2004 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data implicate the miR-17∼92 cluster as part of a regulatory mechanism necessary to maintain MEIS1/HOXA9 -mediated transformation in MLL leukemia, indicating that targeting multiple non-homologous miRNAs may be utilized as a novel therapeutic regimen.
|
27123834 |
2016 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Proviral integration-mediated elevated expression of the meningioma 1 (MN1) oncogene suggested MN1 acting as cooperating event in mixed-lineage leukemia 1 (MLL) and eleven nineteen leukemia (ENL)-induced murine leukemia.
|
20072157 |
2010 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Compared with acute lymphoblastic leukemia (ALL) in older children, ALL in infants has a dismal outcome because rearrangements of the mixed-lineage leukemia (MLL) gene occur in about 80% of these patients, leading to an aggressive type of leukemia.
|
20425430 |
2009 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Insights from clinical studies into the role of the MLL gene in infant and childhood leukemia.
|
17905612 |
2008 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In support of the role of MOF in sustaining H4K16 acetylation, a small-molecule inhibitor of the HAT component MYST blocked the growth of both murine and human <i>MLL-AF9</i> leukemia cell lines.
|
28202522 |
2017 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We review here the leukemia cell lines that have been described to carry 11q23 translocations and MLL fusion genes.
|
14671638 |
2004 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Since the identification of the MLL gene two decades ago, a substantial amount of information has been obtained regarding the mechanisms by which MLL mutations cause leukemia.
|
25773519 |
2015 |
|
Childhood Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
As dysregulated homeobox gene expression is also a feature of MLL-rearranged leukemia, the gene expression signatures of NPM1-mutated and MLL-rearranged leukemias were compared.
|
17597811 |
2007 |