|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, involvement of other genes at 11q23 both centromeric and telomeric of MLL has been identified in different subtypes of leukemia and lymphoma.
|
7529550 |
1994 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
New translocation t(2;13)(p12;q34) and rearrangement of the MLL gene in a childhood leukemia cell line.
|
7536459 |
1995 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine whether 11q23/MLL rearrangements were present in the leukemia cells of patients with a normal karyotype, we performed FISH and molecular studies of eight of these patients who had adequate material.
|
7643616 |
1995 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The MLL/MEN fusion was consistent in all three cases of the t(11;19)(q23;p13.1)-carrying leukemia examined by RNA-based polymerase chain reaction.
|
7718874 |
1995 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ALL-1 gene rearrangements in DNA topoisomerase II inhibitor-related leukemia in children.
|
7756657 |
1995 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rare congenital forms of lymphoid or myeloid leukemia, manifested at birth or during the first month of life, carry a dismal prognosis, especially when a MLL/11q23 rearrangement is present; such cases should be carefully distinguished by chromosomal/molecular analysis and cell culture techniques from transient myeloproliferative disorders which require only supportive care but close follow-up for subsequent development of leukemia.
|
7769837 |
1995 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We previously cloned a gene called ALL-1 which spans the 11q23 breakpoint and is rearranged in most cases of leukemia with 11q23 abnormalities.
|
8275471 |
1994 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Southern blot analysis with the partial cDNA clone for the MLL gene at 11q23 which we had isolated previously detected gene rearrangements in all three cell lines and three leukemia samples from the patients with t(11;19) translocation, indicating that these breakpoints were clustered within the 8.5 kb BamHI germline fragment detected by the probe.
|
8320170 |
1993 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that ALL-1 rearrangements are new molecular markers of human leukemia with considerable diagnostic and prognostic relevance.
|
8339294 |
1993 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Only one of the four cases with MLL rearrangement showed features typical of leukemia with 11q23 aberration; other cases were indistinguishable from those without MLL rearrangement.
|
8616778 |
1996 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Of interest, this same chromosome 5q31 region has also been implicated in MLL gene rearrangements in human leukemia.
|
8769569 |
1996 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia.
|
9122235 |
1997 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We describe a 72-year-old woman suffering from MDS-derived overt leukemia with trisomy 11 and a tandem duplication of the MLL gene.
|
9136917 |
1997 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
None of the high-risk features predictive of poor treatment outcome in childhood ALL, such as older age, high white blood cell (WBC) count, organomegaly, T-lineage immunophenotype, ability of leukemic cells to cause overt leukemia in severe combined immunodeficient (SCID) mice, presence of MLL-AF4, and BCR-ABL fusion transcripts were associated with high levels of BCL-2 expression.
|
9160683 |
1997 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Both fusion products retain the histone acetyltransferase domain of CBP and may lead to leukemia by promoting histone acetylation of genomic regions targeted by the MLL AT-hooks, leading to transcriptional deregulation via aberrant chromatin organization.
|
9238046 |
1997 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data, when combined with those of others, suggest that the fusion point within the AF9 gene, and thus the amount of AF9 material included in the MLL-AF9 fusion gene product, may influence the phenotype of the resulting leukemia.
|
9331569 |
1997 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chimeric MLL products with a Ras binding cytoplasmic protein AF6 involved in t(6;11) (q27;q23) leukemia localize in the nucleus.
|
9349501 |
1997 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Data were combined from seven published molecular studies that examined MLL abnormalities in infants with leukemia.
|
9379688 |
1997 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Translocations of the MLL gene at chromosome band 11q23 are the most common cytogenetic alterations in de novo leukemia in infants and in leukemia related to chemotherapy with DNA topoisomerase II inhibitors.
|
9523205 |
1998 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
MLL genomic breakpoint distribution within the breakpoint cluster region in de novo leukemia in children.
|
9703001 |
1998 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A strong DNase I hypersensitive site (HS) also mapped near exon 9 in four leukemia cell lines, including two in which MLL was rearranged [a t(6;11) and a t(9;11)], and in two lymphoblastoid cell lines with normal MLL.
|
9808573 |
1998 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Jumping translocation with MLL gene rearrangement is a previously unreported phenomenon in leukemia cytogenetics.
|
10092126 |
1999 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further analysis of MSF may help to delineate the function of MLL partner genes in leukemia, particularly in therapy-related leukemia.
|
10339604 |
1999 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rearrangements involving the MLL gene at chromosome 11q23 are associated with leukemia and are present in up to 70% of infant leukemias.
|
10381524 |
1999 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Monitoring of minimal residual leukemia in patients with MLL-AF9 positive acute myeloid leukemia by RT-PCR.
|
10516752 |
1999 |