Leukemia, Myelocytic, Acute
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we studied the distribution and characteristics of Tregs in the LHME, investigated the effects of Treg ablation on leukemia progression, explored the mechanisms leading to Treg accumulation, and studied whether blocking Treg migration to the LHME delayed leukemia progression in MLL-AF9-induced mouse acute myeloid leukemia (AML) models using wildtype (WT) and Foxp3<sup>DTR/GFP</sup> mice.
|
31669202 |
2020 |
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Rearrangement of the mixed lineage leukemia (MLL; also known as lysine methyltransferase 2A) gene is a recurrent genomic aberration in acute myeloid leukemia (AML).
|
31789407 |
2020 |
Leukemia, Myelocytic, Acute
|
0.600 |
Biomarker
|
disease |
BEFREE |
Based on these findings, we treated two different mouse models of MLL-AF9 AML with YKL-05-099, which attenuated disease progression in vivoand extended animal survival at well-tolerated doses.
|
31697837 |
2020 |
Leukemia, Myelocytic, Acute
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cytogenetic and molecular genetic characterization of KMT2A-PTD positive acute myeloid leukemia in comparison to KMT2A-Rearranged acute myeloid leukemia.
|
31698332 |
2020 |
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A highly potent, selective inhibitor, GNF362, ameliorated acute GVHD without impairing GVL against two acute myeloid leukemia lines (MLL-AF9-eGFP; C1498-luciferase).
|
31697815 |
2020 |
Leukemia, Myelocytic, Acute
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we characterize the in vivo migratory behavior of AML cells and their response to chemotherapy and CXCR4 antagonism, using high-resolution 2-photon and confocal intravital microscopy of mouse calvarium BM and the well-established MLL-AF9-driven AML mouse model.
|
30422351 |
2019 |
Leukemia, Myelocytic, Acute
|
0.600 |
Biomarker
|
disease |
BEFREE |
Using a metabolic imaging system with a highly responsive genetically encoded metabolic sensor, SoNar, we reveal that SoNar-high cells are more glycolytic, enriched for higher LIC frequency, and develop leukemia much faster than SoNar-low counterparts in an MLL-AF9-induced murine acute myeloid leukemia model.
|
30581117 |
2019 |
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Microarray-detected high <i>BRE</i> gene expression has been found to be associated with better patient survival in AML (acute myeloid leukemia) with MLL-AF9 translocation, and radiotherapy-treated non-familial breast cancer.
|
31111759 |
2019 |
Leukemia, Myelocytic, Acute
|
0.600 |
Biomarker
|
disease |
BEFREE |
Six iNUP98-KMT2A mice developed transplantable acute myeloid leukemia with leukemic blasts infiltrating multiple organs.
|
31558671 |
2019 |
Leukemia, Myelocytic, Acute
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we assessed the role of p53 in MDS and AML cells treated with decitabine using mouse models for MLL-AF9-driven AML and mutant ASXL1-driven MDS/AML.
|
31160638 |
2019 |
Leukemia, Myelocytic, Acute
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We report that Evi1 reduced the maturation of leukemic cells and promoted the abundance, quiescence, and activity of LSCs in an MLL-AF9-driven mouse model of AML. atRA further augmented these effects in an Evi1 dependent manner.
|
31822659 |
2019 |
Leukemia, Myelocytic, Acute
|
0.600 |
Biomarker
|
disease |
BEFREE |
Chromosomal translocation-induced expression of the chromatin modifying oncofusion protein MLL-AF9 promotes acute myelocytic leukemia (AML).
|
30528456 |
2019 |
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Translocation (9;11)(p21.3;q23.3) is one of the most common lysine methyltransferase 2A (KMT2A)-rearrangements in <i>de novo</i> and therapy-related acute myeloid leukemia (AML).
|
31807181 |
2019 |
Leukemia, Myelocytic, Acute
|
0.600 |
Biomarker
|
disease |
BEFREE |
In summary, our findings demonstrate that MN1 plays an essential role in MLL fusion leukemias and serve as a therapeutic target in MLL-rearranged acute myeloid leukemia.
|
31413090 |
2019 |
Leukemia, Myelocytic, Acute
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here we show that an orally active inhibitor of p53-MDM2 interaction, DS-5272, causes dramatic tumor regressions of MLL-AF9-driven AML in vivo with a tolerable toxicity.
|
31653912 |
2019 |
Leukemia, Myelocytic, Acute
|
0.600 |
Biomarker
|
disease |
BEFREE |
MLL-ENL target genes were induced more efficiently in neonatal progenitors than in adult progenitors, consistent with the distinct AML initiation efficiencies.
|
31405949 |
2019 |
Leukemia, Myelocytic, Acute
|
0.600 |
Biomarker
|
disease |
BEFREE |
Homogeneously staining region (hsr) on chromosome 11 is highly specific for KMT2A amplification in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).
|
31425921 |
2019 |
Leukemia, Myelocytic, Acute
|
0.600 |
Biomarker
|
disease |
BEFREE |
Overall, our data showed that Six1 is essential for the progression of MLL-AF9-induced AML via maintaining the pool of LSC.
|
31050834 |
2019 |
Leukemia, Myelocytic, Acute
|
0.600 |
Biomarker
|
disease |
BEFREE |
The PAF1c is required for MLL fusion-driven acute myeloid leukemia (AML) through direct regulation of pro-leukemic target genes such as Hoxa9 and Meis1.
|
31031188 |
2019 |
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
While the aberrant translocation of the mixed-lineage leukemia (MLL) gene drives pathogenesis of acute myeloid leukemia (AML), it represents an independent predictor for poor prognosis of adult AML patients.
|
31590682 |
2019 |
Leukemia, Myelocytic, Acute
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thus, a precise characterization of KMT2A-r and the fusion partner genes, especially in CKs, is of interest for managing AML.
|
30974445 |
2019 |
Leukemia, Myelocytic, Acute
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we show that the triple combination of the differentiating agent retinoic acid (RA), the ER stress-inducing drug tunicamycin (Tm), and arsenic trioxide (ATO), able to generate oxidative stress, leads to the death of AML cell lines expressing fusion proteins involving the gene MLL and the internal tandem duplication (ITD) in the FLT3 tyrosine kinase receptor.
|
31834935 |
2019 |
Leukemia, Myelocytic, Acute
|
0.600 |
Biomarker
|
disease |
BEFREE |
Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia.
|
30315824 |
2019 |
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
KDM4/JMJD2 are H3K9- and H3K36-specific demethylases, which are considered promising therapeutic targets for the treatment of acute myeloid leukemia (AML) harboring MLL translocations.
|
31434704 |
2019 |
Leukemia, Myelocytic, Acute
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we demonstrate that the MLL1 histone-methyltransferase complex represents a critical actionable vulnerability in CEBPA-mutated AML.
|
30679799 |
2019 |