|
Adult Acute Myeloblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we found that transforming growth factor β (TGFβ) signaling was upregulated in HSCs from bone marrow of mice with MLL-AF9-induced acute myeloid leukemia (AML) because of excessive production of TGFβ1, especially from megakaryocytes, and overactivation of latent TGFβ1 protein.
|
29307605 |
2018 |
|
Adult Acute Myeloblastic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The specific t(10;11)(p12;q23) MLL translocation is a rare recurrent translocation partner, most commonly seen in pediatric and young adult AML.
|
25081372 |
2015 |
|
Adult Acute Myeloblastic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The ecotropic virus integration site 1 (EVI1) transcription factor is associated with human myeloid malignancy of poor prognosis and is overexpressed in 8-10% of adult AML and strikingly up to 27% of pediatric MLL-rearranged leukemias.
|
23826213 |
2013 |
|
Adult Acute Myeloblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order to clarify relationship between these key actors in methylation mechanisms and their potential impact on patient outcomes, we analysed 195 de novo AML patients for the expression of DNMT3A, 3B (and its non-catalytic variant 3B(NC)) and their correlations with the outcome and the expression of other common prognostic genetic biomarkers (EVI1, NPM1, FLT3ITD/TKD and MLL) in adult AML.
|
23251566 |
2012 |
|
Adult Acute Myeloblastic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rearrangements of the Mixed-Lineage Leukemia (MLL) gene are found in > 70% of infant leukemia, ~ 10% of adult acute myelogenous leukemia (AML), and many cases of secondary acute leukemias.
|
22160057 |
2011 |
|
Adult Acute Myeloblastic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We applied our methods to five cancerous gene expression datasets: leukemia (acute lymphoblastic leukemia [ALL] vs. acute myeloid leukemia [AML]), lung cancer, prostate cancer, breast cancer, and leukemia (ALL vs. mixed-lineage leukemia [MLL] vs. AML).
|
19874631 |
2009 |
|
Adult Acute Myeloblastic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Fluorescence in situ hybridization (FISH) was performed in two acute leukemias (AL), one acute myeloid leukemia (AML) M5a, and one treatment-related-AL (t-AL), to investigate the nature of complex changes accompanying the respective t(9;11)(p22;q23)-MLL/AF9 and t(11;16)(q23;p13.3)-MLL/CBP.
|
15075073 |
2004 |
|
Adult Acute Myeloblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we report the identification of an MLL-SEPT6 fusion transcript in an infant with acute myeloid leukemia (AML)-M4.
|
14506700 |
2003 |
|
Adult Acute Myeloblastic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutation/deletion involving FLT3 D835 are found in more than 20% of cases with MLL intragenic abnormalities compared with 10% of AML with MLL translocation and 5% of adult AML with normal MLL status.
|
12791658 |
2003 |
|
Adult Acute Myeloblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Late-appearing MLL rearrangement arising as a secondary change in adult acute myeloid leukemia.
|
11921290 |
2002 |
|
Adult Acute Myeloblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
1 positivity in 2/3 paediatric and 4/11 adult MLL rearranged acute myeloid leukaemia (AML) but in 0/28 adult AML without MLL rearrangement, thus extending the 100% specificity to adult cases.
|
10583275 |
1999 |
|
Adult Acute Myeloblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study confirms the high frequency of 11q23 chromosomal breakpoint/MLL rearrangement in adult AML and the probable existence of two different entities with different clinical features according to the presence of a balanced or unbalanced cytogenetic abnormality, the latter being not associated with MLL rearrangement.
|
9436917 |
1998 |
|
Adult Acute Myeloblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clinicopathologic features of adult AML with MLL rearrangements may be heterogeneous.
|
8616778 |
1996 |