|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
DPY30 facilitates H3K4 methylation by directly binding to ASH2L in the SET1/MLL complexes and plays an important role in hematologic malignancies.
|
31251903 |
2019 |
|
Hematologic Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The hematological malignancies classified as mixed lineage leukemias (MLL) harbor fusions of the MLL1 gene to partners that are members of transcriptional elongation complexes.
|
28663579 |
2018 |
|
Hematologic Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Both gain-of-function and loss-of-function mutations in hematologic malignancy are restricted to MLL1 and MLL3/MLL4, but emerging data indicate that SETD1A/SETD1B and MLL2 can be critical in leukemia as well.
|
28375985 |
2017 |
|
Hematologic Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
DOT1L inhibition in MLL-rearranged leukemia, EZH2 inhibition in EZH2-mutant or MLL-rearranged hematologic malignancies and SNF5-deficient tumors, BRD4 inhibition in various hematologic malignancies, and BRM inhibition in BRG1-deficient tumors have demonstrated promising anti-tumor effects in preclinical models, and these strategies are currently awaiting clinical application.
|
24522270 |
2014 |
|
Hematologic Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Rearrangements affecting the MLL gene in hematological malignancies are associated with poor prognosis.
|
23735562 |
2013 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A substantial body of literature reveals that septins are overexpressed, downregulated or generate chimeric proteins with MLL in a plethora of solid tumors and in hematological malignancies.
|
21740328 |
2011 |
|
Hematologic Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Chromosomal rearrangements involving the MLL gene have been associated with many different types of hematological malignancies.
|
21900057 |
2011 |
|
Hematologic Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Chromosomal rearrangements involving the MLL gene have been associated with many different types of hematological malignancies.
|
20206559 |
2010 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The MLL gene, located on chromosomal band 11q23, is fused to a large number of different partner genes in hematological malignancies.
|
19380030 |
2009 |
|
Hematologic Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Structural abnormalities involving the mixed-lineage leukemia (MLL) gene on 11q23 have been associated with hematological malignancies.
|
17074587 |
2006 |
|
Hematologic Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A large number of abnormalities involving the MLL gene have been associated with hematological malignancies, including acute myeloblastic leukemias (AML).
|
16102580 |
2005 |
|
Hematologic Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Chromosome translocations disrupting the MLL gene are associated with various hematologic malignancies but are particularly common in infant and secondary therapy-related acute leukemias.
|
16105754 |
2005 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FOXO3 and FOXO4 genes are fused to MLL gene in hematological malignancies.
|
15492844 |
2004 |
|
Hematologic Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The MLL gene, located at 11q23 band, is frequently disrupted by different chromosomal rearrangements that occur in a variety of hematological malignancies.
|
12529663 |
2003 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Paired multiplex reverse-transcriptase polymerase chain reaction (PMRT-PCR) analysis as a rapid and accurate diagnostic tool for the detection of MLL fusion genes in hematologic malignancies.
|
11480574 |
2001 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Restricted chromosome breakpoint sites on 11q22-q23.1 and 11q25 in various hematological malignancies without MLL/ALL-1 gene rearrangement.
|
11165319 |
2001 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cytogenetic and molecular analyses of 11q23/MLL positive hematologic malignancies show that der(11) encodes the critical 5'MLL/3'partner gene transcript.
|
9593288 |
1998 |
|
Hematologic Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We studied MLL rearrangements in five patients with myeloid hematologic malignancies with trisomy 11.
|
9209466 |
1997 |