Disease: Depressed mood ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.050 Biomarker phenotype BEFREE The purpose of this study was to investigate the potential competition inhibition of HAR and HAL on MAO and AChE in brain endothelial cells (RBE4) and in healthy rats to provide a basis for the application of the inhibitors in the treatment of patients with depression and with Parkinson's disease or Alzheimer's disease. 31154274 2019
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.050 GeneticVariation phenotype BEFREE The mean (SD) of the following parameters were: AChE 3.7 U/mL (0.55), depression T-score 53.0 (9.4) and anxiety T-score: 57.6 (9.8). 31202795 2019
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.050 Biomarker phenotype BEFREE This work provides a new and rewarding perspective to elucidate the role of oxidative stress regulating AChE in the pathology of depression. 30638380 2019
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.050 Biomarker phenotype BEFREE It also discusses many other pharmacological approaches that have proven to be inadequate (antipsychotics, acetylcholinesterase inhibitors, anticonvulsants, hormone replacement therapy) and new drug classes (mainly affecting glutamate transmission) that are being studied for treating depression in AD. 29726758 2018
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.050 Biomarker phenotype BEFREE We evaluated the behavioural and molecular effects of a selective serotonin re-uptake inhibitor (SSRI, fluoxetine) and an acetylcholinesterase inhibitor (AChEI, donepezil) on emotional-cognitive endophenotypes of depression and the hippocampal proteome. 29174946 2018