|
Premature Menopause
|
0.310 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Screening for mutations of the FOXO4 gene in premature ovarian failure patients.
|
22285440 |
2012 |
|
Premature Menopause
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Screening for mutations of the FOXO4 gene in premature ovarian failure patients.
|
22285440 |
2012 |
|
Sarcopenia
|
0.210 |
Biomarker
|
phenotype |
BEFREE |
The WNK1-FOXO4 axis may be a potential therapeutic target in human diseases causing sarcopenia.
|
29904119 |
2018 |
|
Sarcopenia
|
0.210 |
Biomarker
|
phenotype |
RGD |
Atrogin-1/MAFbx and MuRF1 are downregulated in aging-related loss of skeletal muscle.
|
16870627 |
2006 |
|
Other alcohol-induced mental disorders
|
0.200 |
Biomarker
|
disease |
RGD |
The role of FoxO4 in the relationship between alcohol-induced intestinal barrier dysfunction and liver injury.
|
23292333 |
2013 |
|
Gastric ulcer
|
0.200 |
Biomarker
|
disease |
RGD |
Moreover, in the rat gastric ulcers, the mRNA transcript levels of IGF-1, PTEN, Akt-1, Akt-2, FoxO3 and FoxO4 were upregulated in the gastric ulcer margin, with a peak between Days 4 and 8 following 7 h of WRS.
|
22735908 |
2012 |
|
Paraplegia
|
0.200 |
Biomarker
|
disease |
RGD |
Gene and protein expression associated with protein synthesis and breakdown in paraplegic skeletal muscle.
|
18236467 |
2008 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
FoxO4, which was initially identified as a tumor suppressor that limits cell proliferation and induces apoptosis, plays diverse roles in cardiovascular diseases.
|
30323875 |
2018 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Moreover, whether FOXO4 acts as a tumor-suppressor or pro-tumoral factor in tumors and the potential directions of future FOXO4 research are discussed.
|
29719213 |
2018 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Immunohistochemical staining for FOXO4 in tumor tissue of diffuse large B-cell lymphoma revealed nuclear localization and significant association with poor prognosis.
|
27911272 |
2017 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
FOXO4 may be a potential therapeutic target for tumor-associated epilepsy.
|
28963932 |
2017 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Forkhead box O4 (FOXO4) has been reported to be a novel tumor suppressor gene in gastrointestinal cancers; however, its role in clear‑cell renal carcinoma cells (ccRCC) has remained largely elusive.
|
26780985 |
2016 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Up-regulating FOXO4 inhibited the growth and metastasis of gastric cancer cell lines in vitro and led to dramatic attenuation of tumor growth, and liver and lung metastasis in vivo, whereas down-regulating FOXO4 with specific siRNAs promoted the growth and metastasis of gastric cancer cell lines.
|
24886657 |
2014 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
There were significant correlations between FoxO4 and TNM stage (P<0.001), histological differentiation (P=0.004) and lymph node metastasis (P<0.001), but no significant links with age (P=0.323), gender (P=0.410), tumor size (P=0.084), smoking status (P=0.721) and histological type (P=0.281).
|
24935588 |
2014 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Most significantly for clinical application, FOXO4A3 expression in HER2-overexpressing cells can be regulated in vivo and reduces the tumor volume in a tumor model.
|
15688030 |
2005 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
The deregulation of FOXO4 is closely linked to the progression of several types of cancer, senescence, and other diseases.
|
31529218 |
2020 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
The deregulation of FOXO4 is closely linked to the progression of several types of cancer, senescence, and other diseases.
|
31529218 |
2020 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Collectively, the information reviewed here should increase the potential of FOXO4 as a therapeutic target for cancer.
|
30515801 |
2019 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Collectively, the information reviewed here should increase the potential of FOXO4 as a therapeutic target for cancer.
|
30515801 |
2019 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
The information reviewed here may assist in the experimental design and increase the potential of FOXO4 as a therapeutic target for cancer.
|
29719213 |
2018 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
The information reviewed here may assist in the experimental design and increase the potential of FOXO4 as a therapeutic target for cancer.
|
29719213 |
2018 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
The role of microRNA-1274a in the tumorigenesis of gastric cancer: accelerating cancer cell proliferation and migration via directly targeting FOXO4.
|
25753202 |
2015 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
The role of microRNA-1274a in the tumorigenesis of gastric cancer: accelerating cancer cell proliferation and migration via directly targeting FOXO4.
|
25753202 |
2015 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Here, we characterize novel FOXO4 phosphorylation sites after increased cellular oxidative stress and identify the isomerase Pin1, a protein frequently found to be overexpressed in cancer, as a critical regulator of p27(kip1) through FOXO4 inhibition.
|
18794148 |
2008 |
|
Primary malignant neoplasm
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Here, we characterize novel FOXO4 phosphorylation sites after increased cellular oxidative stress and identify the isomerase Pin1, a protein frequently found to be overexpressed in cancer, as a critical regulator of p27(kip1) through FOXO4 inhibition.
|
18794148 |
2008 |