FOXO4, forkhead box O4, 4303

N. diseases: 84; N. variants: 1
Disease: Degenerative polyarthritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.030 Biomarker disease BEFREE Col2Cre-FoxO3 and FoxO4 KO mice showed no cartilage abnormalities until 18 months of age when Col2Cre-FoxO3 KO mice had more severe OA than control mice. 29444976 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.030 Biomarker disease BEFREE Deficient PSMD11, associated with reduced phosphorylated FOXO4, promotes impaired proteasomal function in OA chondrocytes, dysregulation of chondrocytic homeostasis, and decreased levels of SOX9 mRNA, SOX9 protein, and AGC1 mRNA. 29457374 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.030 AlteredExpression disease BEFREE Inactivation of FoxO4 was significantly enhanced in the RA as compared with the OA synovial sublining. 17599731 2007