The positive rates of FoxO3 and FoxO4 were lower in the patients with lymph node metastasis than that in the patients without lymph node metastasis (P<0.05), and significantly lower in the patients with non-muscle invasive bladder cancer (T<sub>is</sub>-T<sub>1</sub>) than in those with non-muscle invasive bladder cancer (T<sub>2</sub>-T<sub>3</sub>) in TNM staging, and remarkably lower in the patients with high grade than in those with low grade in the histological type (P<0.05).
There were significant correlations between FoxO4 and TNM stage (P<0.001), histological differentiation (P=0.004) and lymph node metastasis (P<0.001), but no significant links with age (P=0.323), gender (P=0.410), tumor size (P=0.084), smoking status (P=0.721) and histological type (P=0.281).