Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
CTD_human |
Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis.
|
26396155 |
2016 |
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Serum MMP-2 and TIMP-1 levels might be useful for estimating the degree of liver fibrosis.
|
9075665 |
1997 |
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest that increased MMP-2 during the progression of liver fibrosis may be an important mechanism for inhibiting type I collagen synthesis by activated HSCs, thereby providing a protective rather than pathologic role.
|
20563750 |
2011 |
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We examined MMP-2 and MMP-14 expression in established and resolving fibrosis to assess their role in resolution of liver fibrosis.
|
15482348 |
2004 |
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Intrahepatic COX-2, MMP-2, and MMP-9 overexpression is associated with progressive hepatic fibrosis in chronic HCV infection, suggesting their pathogenic role in fibrogenesis.
|
15479690 |
2004 |
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, PS-modified NLCs nanoparticles prolonged the retention time of Cur, and enhanced its bioavailability and delivery efficiency to the livers, resulting in reduced liver fibrosis and up-regulating hepatic expression of HGF and MMP-2.
|
29214887 |
2018 |
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Outcome variables were: a) liver fibrosis (Metavir score) [fibrosis stage (F0, F1, F2, F3 and F4) and advanced fibrosis and cirrhosis (F ≥ 3 and F4, respectively)]; b) non-invasive indexes [FIB-4, APRI, and their cut-offs (FIB-4 ≥ 3.25 and APRI≥1.5)]; c) inflammation-related biomarkers (leptin, HGF, NGF, sFasL, sFas, MIF, HA, Ang-2, TIMP1, MMP1 and MMP2).
|
30336268 |
2019 |
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we detected the key factors involved in liver fibrosis in the mice, revealing significantly increased hydroxyproline concentration; elevated expression of α-smooth muscle actin (α-SMA) and fibrosis-related genes such as Collagen-1, Collagen-3, Mmp2, Mmp13, Timp1, Timp3, and Activin, upregulated Smad3 phosphorylation, and increased serum TGF-β levels.
|
30367152 |
2019 |
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Salidroside inhibited the production of extracellular matrix (ECM) and regulated the balance between MMP2 and TIMP1 and, therefore, alleviated liver fibrosis in the two fibrosis models.
|
29970958 |
2018 |
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Consistent with the results of in vitro study, intrahepatic IFN-γ/STAT1 levels increased in relation to the severity of liver fibrosis in BA patients, and the altered balance between MMP2 and TIMP1 expressions in livers may contribute to increased deposition of extracellular matrix and fibrosis.
|
28304404 |
2017 |
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The mechanism of development of liver fibrosis involves activation of Matrix metalloproteinase-2 (MMP-2) and Matrix metalloproteinase-9 (MMP-9), upregulation of HIF-1α transcriptional activity and its related factors, NF-κB and TGF-β.
|
27260943 |
2017 |
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
CTD_human |
Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression.
|
15763341 |
2005 |
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We studied matrix metalloproteinase-2 (MMP-2), -7, -9 and -13 mRNA expressions in the liver tissue of early-stage biliary atresia at the time of Kasai's procedure, late-stage biliary atresia at the time of liver transplantation with advanced fibrosis and nondiseased control without liver fibrosis.
|
15696117 |
2005 |
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study verified differential expression of MMPs and TIMPs in different stages of BA, with emphasis on the role of TIMP-1, -2, and -3 as well as MMP-2, -7, and -9 transcripts in remodeling of liver tissue during the progress of BA-associated liver fibrosis.
|
16226986 |
2005 |
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl₄-intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression.
|
23734997 |
2013 |
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In liver fibrosis in both human and mouse tissue MMP expression and activity (MMP-2, -9, -13 and -14) increased with progressive injury and localised to hepatocytes.
|
25076423 |
2014 |
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
The increased MMP-2/TIMP-2 and suppressed MMP-9/TIMP-1 ratios in IHC and in real-time polymerase chain reaction (RT-PCR) seemed to correlate with the degree of liver fibrosis.
|
30019784 |
2018 |