|
Endometriosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The phosphorylation of ERK and JNK was observed when <i>U. urealyticum</i> was added to PMCs and knock out of Tlr2 inhibited these MAPKs phosphorylation.Based on our co-culture study, <i>U. urealyticum</i>-infected PMCs exhibited significantly increased attachment to ESCs compared with uninfected PMCs.Collectively, <i>U. urealyticum</i> infection promotes the development of endometriosis by increasing inflammatory mediators, adhesion molecules, and MMP-2 expression in PMCs through TLR2 signaling.
|
31636643 |
2019 |
|
Endometriosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Matrix metalloproteinases (MMPs), especially the gelatinases MMP-2 and MMP-9, play a crucial role in the pathogenesis of endometriosis by enabling invasion.
|
30981279 |
2019 |
|
Endometriosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
This study aimed at investigating the effects of Resveratrol on expression of MMP-2 and -9 in endometriosis patients.
|
30777471 |
2019 |
|
Endometriosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
MicroRNA-2861 targets STAT3 and MMP2 to regulate the proliferation and apoptosis of ectopic endometrial cells in endometriosis.
|
30940310 |
2019 |
|
Endometriosis
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
Our findings suggest that changes in DNA methylation at the promoter region of MMP2 could underlie the changes in its expression in the ectopic endometria from patients with endometriosis.
|
29266528 |
2018 |
|
Endometriosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Compared with those with endometriosis or normal endometria, the positive rate of MMP-2 expression is significantly higher in patients with endometrial cancer (RR = 2.31, 95% CI: 1.78-3.00, P < .01).
|
30024495 |
2018 |
|
Endometriosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Results of RT-qPCR revealed that mRNA expression of LC3 and Beclin1 in the endometrium of patients in the EM group were obviously decreased compared with those in the control group, while the expression of MMP-2 was high, and differences in expression were statistically significant (P<0.05).
|
30186424 |
2018 |
|
Endometriosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Moreover, EMs mice treated with rhIL-37 showed the decreased endometriotic-like lesion size and lesion weight, lower expression of IL-1β, IL-6, IL-10, TNF-α, vascular endothelial growth factor (VEGF), soluble intercellular adhesion molecule-I (ICAM-I) and MMP-2/9 activity in peritoneal fluid compared with the wide type (WT) EMs mice.
|
29924731 |
2018 |
|
Endometriosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the deficiency of TNFRp55 promoted the establishment and development of endometriosis through an increase in the lesion size and high levels of estradiol which correlate with an increase in the MMP-2 activity.
|
28676525 |
2017 |
|
Endometriosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
In addition, increased MT1MMP and decreased tissue inhibitors of metalloproteinases (TIMP)-2 expressions were found in the late stages of endometriosis indicating more MMP-2 activation with disease progression.
|
27695098 |
2016 |
|
Endometriosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Matrix metalloproteinase-2 (MMP-2), MMP-9, tissue inhibitor of matrix metalloproteinases (TIMP-1) and transforming growth factor-β2 (TGF-β2) expression in eutopic endometrium of women with peritoneal endometriosis.
|
28030938 |
2016 |
|
Endometriosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Real-time polymerase chain reaction for detecting CD147 expression in 60 human endometriosis lesions; migration assay and CellTiter 96 AQueous One Solution Cell Proliferation Assay (MTS) assay for cell functional investigation; Western blot for detecting protein levels; gelatin zymography for evaluating the activity of matrix metalloproteinase-2 (MMP-2) in cultured cells.
|
24661733 |
2014 |
|
Endometriosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Matrix metalloproteinase 2 (MMP-2) has been reported to be an important regulator of cell migration and invasion through degradation of the extracellular matrix (ECM) in many diseases, such as cancer and endometriosis.
|
23855590 |
2013 |
|
Endometriosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Further, a significantly higher endometrial expression of MMP-2 and -9 were observed in women with endometriosis when compared with controls.
|
23979130 |
2013 |
|
Endometriosis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We investigated the role and function of single-nucleotide polymorphisms (SNP) of MMP2 in relation to endometriosis.
|
23364396 |
2013 |
|
Endometriosis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The MMP-2 and TIMP-2 polymorphisms are associated with advanced-stage endometriosis.
|
22985025 |
2013 |
|
Endometriosis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The results demonstrated that polymorphisms in MMP-2 (-735 C/T) and MMP-9 (-1562 C/T) were associated with elevated risk of endometriosis and that certain MMP-2 promoter haplotypes were more common in control group.
|
20100617 |
2010 |
|
Endometriosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Autologous peritoneal fluid stimulated MMP-2 mRNA expression in eutopic endometrium of women with endometriosis.
|
20056200 |
2010 |
|
Endometriosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
An increase of MMP-2 mRNA expression was only detected after 96 hours of CAM culture in patients with and without endometriosis.
|
19345347 |
2010 |
|
Endometriosis
|
0.300 |
Biomarker
|
disease |
RGD |
Autologous peritoneal fluid stimulated MMP-2 mRNA expression in eutopic endometrium of women with endometriosis.
|
20056200 |
2010 |
|
Endometriosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Although the MMP-2 promoter lacks a canonical progesterone response element (PRE), the hormone inhibits MMP-2 expression and is part of treatment protocols in gynecological invasive pathologies, including endometriosis and endometrial hyperplasia.
|
19426551 |
2009 |
|
Endometriosis
|
0.300 |
Biomarker
|
disease |
LHGDN |
MMP-2 and MMP-9, and E-cadherin expressions were significantly higher and beta-catenin expression was significantly lower in endometriosis as compared to endometrioid carcinoma.
|
18295959 |
2008 |
|
Endometriosis
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
No significant difference was found in allele frequencies and genotype distributions of MMP-2 -1306C/T polymorphism between endometriosis patients and control women (P> 0.05).
|
18543216 |
2008 |
|
Endometriosis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Association of polymorphisms of the MMP-2 and TIMP-2 genes with the risk of endometriosis in North Chinese women.
|
18177649 |
2008 |
|
Endometriosis
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
Association of polymorphisms of the MMP-2 and TIMP-2 genes with the risk of endometriosis in North Chinese women.
|
18177649 |
2008 |