Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
p85α Inactivates MMP-2 and Suppresses Bladder Cancer Invasion by Inhibiting MMP-14 Transcription and TIMP-2 Degradation.
|
31401412 |
2019 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The identification of the miR-146b/AUF1/ETS2/MMP2 mechanism for promoting bladder cancer invasion provides significant insights into understanding the nature of bladder cancer metastasis.
|
31071529 |
2019 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
XIAP Interaction with E2F1 and Sp1 via its BIR2 and BIR3 domains specific activated MMP2 to promote bladder cancer invasion.
|
31811115 |
2019 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our previous studies have demonstrated that XIAP promotes bladder cancer metastasis through upregulating RhoGDIβ/MMP-2 pathway.
|
31240993 |
2019 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
MMP-2 and MMP-9 as prognostic markers for the early detection of urinary bladder cancer.
|
30548095 |
2019 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness.
|
29588320 |
2018 |
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Exogenous H2S may promote cell proliferation and invasion by upregulating the expression level of MMP2 and MMP9 in human bladder cancer EJ cells.
|
29237912 |
2017 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of MMP-2, RB and PAI-1 with decreased recurrence-free survival and overall survival in bladder cancer patients.
|
29245935 |
2017 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings, together with our previous results showing X-link inhibitor of apoptosis protein mediating mRNA stabilization of both RhoGDIβ and mmp-2, reveal the nature of the MMP-2 regulatory network, which leads to MMP-2 overexpression and BC invasion.
|
28846829 |
2017 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For the MMP2 -1306 C/T polymorphism, there was a negative association with the T allele for bladder cancer in the Asian population (TT+TC vs. CC: OR = 0.41, 95% CI = 0.18-0.94, pheterogeneity = 0.195).
|
26301605 |
2015 |
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
RNA interference of HMGB3 in UBC cell lines inhibited cancer cell growth and migration, along with the downregulation of PCNA and MMP2 protein levels.
|
25647262 |
2015 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein, we report the novel concept that miR-20b exerts a suppressive effect on both cell cycle-modulated proliferation and MMP-2-mediated migration and invasion in bladder cancer EJ cells.
|
26166554 |
2015 |
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of GATA3 in the bladder cancer lines (5637, TCC-SUP, J82) resulted in promotion of cell migration and invasion as well as increases in the expression of their related molecules, such as vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9, and the activity of MMP-2 and MMP-9.
|
24448324 |
2014 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The MMP-1, MMP-2, and MMP-9 gene polymorphisms and susceptibility to bladder cancer: a meta-analysis.
|
24390660 |
2014 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Individuals with MMP2 (-1306) TT genotype as well as T allele were at higher risk of BC (P, 0.042; OR, 2.85; P, 0.001; OR, 1.76).
|
21784671 |
2013 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The combined genotype MMP2 -1306C/T (rs243865) allele T with MMP9 -1562C/T (rs3918242) allele T was found to increase BC risk (OR 2.00, 95% CI 1.10-3.62; P = 0.022).
|
23819551 |
2013 |
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of survivin RNA and matrix metalloproteinase 2 and 9 in bladder cancer was compared with benign and normal cases.
|
22960341 |
2013 |
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MMP-9, MMP-2 and its specific inhibitors expression levels were analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) in fresh-frozen malignant tissue collected from 40 patients with BC submitted to transurethral resection of bladder.
|
22695075 |
2012 |
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found that KAI1 expression in bladder cancer cell lines is related to a poor invasive potential and expression of latent MMP-2 but not MMP-9.
|
20864363 |
2012 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the effect of TGF-beta(2) on MMP-2 regulation in human bladder carcinoma cell line 5637.
|
19219652 |
2009 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Similarly, the MMP-2 to TIMP-2 ratio also showed statistically significant difference between normal bladder tissue and bladder carcinoma (P < 0.01).
|
12133547 |
2002 |
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results demonstrate that the induced expression of human gelatinase A enzyme markedly accelerates the metastatic phenotype of the rat bladder carcinoma cell line MYU3L.
|
7591268 |
1995 |