|
Neoplasm Metastasis
|
0.300 |
GeneticVariation
|
phenotype |
BEFREE |
Matrix metalloproteinase (MMP)-1 and MMP-3 genes are associated with tumor cell invasion and metastasis with their promoter polymorphisms influencing the level of transcription.
|
12432557 |
2002 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
We concluded that overexpression of MMP-3 and uPA, altogether with diminished expression of PAI-1 from metastatic tumors, might be a crucial step towards metastasis in ductal breast cancer.
|
27975070 |
2016 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Our results demonstrated that MMP-3 expression is deregulated in osteosarcomas and this potentially contributes to metastasis and might be a promising marker for the prognosis and therapy of metastatic osteosarcoma.
|
27061553 |
2016 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Further, we suggest a role for MT1-MMP in early tumour progression, expression of MMP-1 during metastasis and focal expression pattern of MMP-3 in areas of expansion.
|
17669621 |
2008 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
RGD |
Gel zymography showed increase in MMP2 and MMP3 activity in brain metastasis.
|
16158251 |
2005 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
NFAT1 Directly Regulates IL8 and MMP3 to Promote Melanoma Tumor Growth and Metastasis.
|
27013197 |
2016 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
However, whether MMP-3 participates in the regulation of metastasis and its mechanisms in glioma is mostly unknown.
|
25252846 |
2014 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Together, our findings demonstrate that PAFR can activate ERK1/2 pathway, and subsequently increase MMP-3 expression and decrease E-cadherin expression, which finally promote prostate cancer cell growth, invasion and metastasis.
|
27176648 |
2016 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
What is more, miR-519d expression was inversely correlated with MMP3 expression in OSCC tissues, and high levels of MMP3 expression in OSCC tissues were also associated with the metastasis and poor prognosis of these patients.
|
31258780 |
2019 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Matrix metalloproteinase-1 and matrix metalloproteinase-3 are implicated in all steps of cancer initiation, invasion, and metastasis.
|
16937230 |
2006 |
|
Neoplasm Metastasis
|
0.300 |
GeneticVariation
|
phenotype |
BEFREE |
For MMP3 (-1171) 5A/6A, the polymorphism decreased the overall risk of metastasis under two genetic models (recessive: OR = 0.80, 95%CI = 0.64-0.99, dominant: OR = 0.72, 95%CI = 0.56-0.93).
|
22348060 |
2012 |
|
Neoplasm Metastasis
|
0.300 |
GeneticVariation
|
phenotype |
BEFREE |
This study examined the association between genotypes and haplotypes in the MMP1-MMP3-MMP12 gene cluster and risk of lung cancer development and metastasis.
|
17145822 |
2006 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
CAV-1 might increase the cell metastasis potential through the interaction with E-cadherin and MMP-3 genes.
|
19718715 |
2009 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Our results indicate that Cav-1 and CD147 overexpression predict poor NPC prognosis and enhanced tumor cell migration, which is associated with MMP-3 and MMP-11 (active) secretion.
|
19582878 |
2009 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
CTPS2, TP53I3 and SLC1A1 may serve major roles in osteosarcoma development, and hsa‑miR‑422a, hsa‑miR‑194, MMP3 and VEGFB may be associated with osteosarcoma metastasis.
|
31173206 |
2019 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
C/EBPβ Promotion of MMP3-Dependent Tumor Cell Invasion and Association with Metastasis in Colorectal Cancer.
|
29172775 |
2018 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
This pathway transcriptionally activated the matrix metalloproteinase-3 gene and promoted oral SCC cell proliferation and experimental metastasis in vivo.
|
12917446 |
2003 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Our results demonstrated that MMP-3 expression is deregulated in osteosarcomas and this potentially contributes to metastasis and might be a promising marker for the prognosis and therapy of metastatic osteosarcoma.
|
27837634 |
2017 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
LHGDN |
Gel zymography showed increase in MMP2 and MMP3 activity in brain metastasis.
|
16158251 |
2005 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Overall, our data suggest that AA6 determines an α-KG-dependent epigenetic regulation of the TET-miR200-Zeb1/CtBP1-MMP3 axis providing an anti-metastatic effect in a mouse model of breast cancer-associated metastasis.
|
29988033 |
2018 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Therefore, we hypothesized that MMP3 governed later stages of disease, including progression to metastasis, and did so through a novel IRF8-MMP3 axis.
|
26008967 |
2015 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
We suggest that the integrin alpha v beta 6 is a key component of oral SCC invasion and metastasis through modulation of MMP-3 activity.
|
12009335 |
2002 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
The CCAAT/enhancer binding protein β (C/EBPβ) and matrix metalloproteinase 3 (MMP3) are thought to play key roles in cancer invasion and metastasis.
|
30969151 |
2019 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
The disease-free survival of patients with high levels of MMP-3 expression in their metastases (> or = 20% positive tumor cells, n = 14) was also significantly shorter compared to patients with lower levels of expression (n = 42) (median 5.1 vs. 14.0 months, p = 0.0294).
|
11802203 |
2002 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Data from our study suggest that T3/TR, miR-17, p-AKT and MMP3 activities are interlinked in the regulation of cancer cell metastasis.
|
23912452 |
2013 |