MMP3, matrix metallopeptidase 3, 4314

N. diseases: 473; N. variants: 24
Disease: Tumor Progression ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.050 AlteredExpression phenotype BEFREE To the best of our knowledge, this is the first study to demonstrate the crucial role of reactive oxygen species in the switching expression of MMP-3 in stromal fibroblasts and prostate cancer cells during tumor progression, clarifying how the tumor microenvironment modulates ECM homeostasis control. 28831065 2017
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.050 AlteredExpression phenotype BEFREE Altogether, we showed an inverse mechanistic relationship between IRF8 and MMP3 expression in tumor progression. 26008967 2015
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.050 Biomarker phenotype BEFREE Evidence has shown that matrix metalloproteinases-3 (MMP3) is important for cancer progression. 24489939 2014
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.050 AlteredExpression phenotype BEFREE The autocrine motility factor (AMF) is a multifunctional protein that is involved in tumor progression including enhanced invasiveness via induction of matrix metalloproteinase-3 (MMP3). 18485900 2008
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.050 GeneticVariation phenotype BEFREE The results do suggest that, in women with breast cancer, a high-expressing MMP-3 genotype may promote tumor progression more effectively. 17922906 2007