Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
A disintegrin and metalloproteinase 33 (ADAM33) and matrix metalloproteinase-9 (MMP9) appear to have important roles in asthma and COPD pathogenesis.
|
17403951 |
2007 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Additionally, the significant inverse relationships between parameters of lung function (FEV<sub>1</sub>% and FEV<sub>1</sub>/FVC) and proteins level were found in ridge regression models, especially we found that FEV<sub>1</sub>% decreased when MMP-9 level increased in controls and patients with COPD group.
|
30643813 |
2018 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The level of MMP-9 was significantly higher in COPD patients with >3 comorbidities, a COTE index of ≥4 and cardiovascular disease as well as coronary heart disease (t=6.40, 2.53, 3.65 and 2.90, P<0.05).
|
30542429 |
2018 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
On the other hand, subgroup analysis suggested that MMP9 -1562 C/T polymorphism was related to COPD, as we found that C allele carriers were at lower risk in some subgroups stratified by lung function, age and genotype identification method, compared with TT homozygotes.
|
24085258 |
2013 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Moreover, inhibiting Src deterred the cigarette smoke-mediated induction of matrix metalloproteinase-9 and -12 in alveolar macrophages and lung expression of cathepsin K, IL-17, TNF-α, MCP-1, and KC, all key factors in the pathogenesis of COPD.
|
24111605 |
2014 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
While the triad discriminated between smokers and non-smokers in the COPD group, MMP-9 and proMMP-9/NGAL (but not NGAL) discriminated between smokers with and without COPD.
|
28004483 |
2017 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we examined the relationship between circulating serpina3g, matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinase-1 and -2 (TIMP-1 and -2, respectively) and severity of COPD.
|
30781876 |
2019 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
There was no difference in polymorphism of MMP-9 (C-1562T) between patients with COPD and control subjects.
|
16126934 |
2005 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Additionally, specific activation of phosphoinositide 3‑kinase (PI3K) signaling, using insulin‑like growth factor‑1 (IGF‑1), promoted cell proliferation and cell cycle progression, increased expression of TGFβ1, FGF‑1, PI3K, AKT, phospho‑AKT, serine/threonine‑protein kinase mTOR (mTOR), phospho‑mTOR and TIMP1, promoted cell migration capacity and reduced the expression level of MMP‑9 in cells from COPD rats.
|
30066869 |
2018 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Cutaneous expression of MMP-9 mRNA and proMMP-9 concentrations was increased in exposed skin of COPD patients (p=0.004 and p=0.02, respectively) and was also associated with increased skin elastin degradation (r=0.62, p<0.001 and r=0.47, p=0.01, respectively).
|
22374923 |
2012 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Therefore, this study aimed to evaluate the effect of conjugated linoleic acid (CLA) supplement as natural antioxidants on oxidative stress levels, and MMP2 and MMP9 serum levels in COPD patients.
|
29765212 |
2018 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
According to source of controls, significant association of MMP-9 -1562 C/T (additive model: T vs C; OR:1.71, 95% CI: 1.42-2.07; p<0.00001, and dominant model; OR: 1.92; 95% CI: 1.34-2.76; p = 0.0004) with COPD susceptibility was revealed in the subgroup with smoker-based controls.
|
23555986 |
2013 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Serum CyPA positively correlated with serum interleukin-6, matrix metalloproteinase-9 and high-sensitivity C-reactive protein in both the exacerbation and convalescence phases of COPD.
|
29403273 |
2018 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
The levels of innate defense proteins associated with chronic obstructive pulmonary disease, such as elastase and matrix metalloproteinase-9, were significantly elevated in e-cigarette users as well.
|
29053025 |
2018 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here we review evidence that genetic polymorphisms in matrix metalloproteinase genes MMP1, MMP9 and MMP12 may be important in the development of COPD.
|
12383023 |
2002 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Baseline plasma concentration of anti-elastin antibodies and elastin-degrading enzymes (eg, matrix metalloproteinase-9, and -12, and neutrophil elastase) were measured in the same cohort. elastin fragment-specific CD 4<sup>+</sup> T cell expression of interferon-γ, and anti-elastin antibodies were dependent on history of smoking in TAA / TAD patients but were independent of chronic obstructive pulmonary disease.
|
30957625 |
2019 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
By anchoring MMP-8 and MMP-9 to PMN surfaces, membrane-bound TIMP-1 plays a counterintuitive role in promoting PMN pericellular proteolysis occurring in chronic obstructive pulmonary disease and other diseases.
|
31019060 |
2019 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
LPS-stimulated release of IL-6 and MCP-1 was greater from COPD patient's monocytes relative to controls, while activation of control cells resulted in enhanced secretion of ICAM-1 and MMP-9 compared to COPD patients.
|
14624669 |
2003 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The genetic polymorphism in promoters of MMP-9 gene is associated with the susceptibility to COPD in the Han population of South China.
|
15498369 |
2004 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A COPD model was employed by exposing mice to cigarette smoke and the expression levels of MMP-9 and MMP-12 were significantly increased in the lungs.
|
29358724 |
2018 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Finally, the authors refer to the studies on MMP-9 inhibition as a new perspective for increasing the effectiveness of treatment in asthma and COPD.
|
26123447 |
2016 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that the MMP-9 -1562C-->T polymorphism could be used as a marker for determining the genetic susceptibility to COPD in a Korean population.
|
20160424 |
2010 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Serum MMP-9 concentrations were significantly higher in the COPD than in the non-COPD group.
|
25332229 |
2014 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Inappropriate elevation of matrix metalloproteinase-9 (MMP9) is reported to be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD).
|
19376817 |
2009 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Combinations of genetic variants including *2A homozygotes of CYP1A1 and T alleles in MMP-9 are significant indicators for susceptibility to COPD.
|
19507017 |
2009 |