Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here we review evidence that genetic polymorphisms in matrix metalloproteinase genes MMP1, MMP9 and MMP12 may be important in the development of COPD.
|
12383023 |
2002 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Matrix metalloproteinase (MMP)-9 (Gelatinase B, 92-kD type IV collagenase, EC 3.4.24.35) is an MMP that is present in low quantities in the healthy adult lung, but much more abundant in several lung diseases, including asthma, idiopathic pulmonary fibrosis (IPF), and chronic obstructive pulmonary disease (COPD).
|
12495928 |
2003 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
LHGDN |
Matrix metalloproteinase-9 release from human leukocytes.
|
12861851 |
2003 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
LPS-stimulated release of IL-6 and MCP-1 was greater from COPD patient's monocytes relative to controls, while activation of control cells resulted in enhanced secretion of ICAM-1 and MMP-9 compared to COPD patients.
|
14624669 |
2003 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
In conclusion, this study shows that MMP-9 expression in human lung parenchyma is associated with cigarette smoking and also with the obstruction of airflow, suggesting that MMP-9 may play a role in the pathogenesis of the cigarette smoke-induced obstruction of airflow known as the characteristic of COPD.
|
14676438 |
2003 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The genetic polymorphism in promoters of MMP-9 gene is associated with the susceptibility to COPD in the Han population of South China.
|
15498369 |
2004 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
There was no difference in polymorphism of MMP-9 (C-1562T) between patients with COPD and control subjects.
|
16126934 |
2005 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
There was no difference in polymorphism of MMP-9 (C-1562T) between patients with COPD and control subjects.
|
16126934 |
2005 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Genotypes in matrix metalloproteinase 9 are risk factors for chronic obstructive pulmonary disease.
|
16395864 |
2005 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
A disintegrin and metalloproteinase 33 (ADAM33) and matrix metalloproteinase-9 (MMP9) appear to have important roles in asthma and COPD pathogenesis.
|
17403951 |
2007 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production.
|
18006877 |
2008 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
As the major clinical characteristics of stage 4 COPD is the development of pulmonary emphysema as well as bronchial walls deformation, we suggest that the increased expression of MMP9 gene caused by genetic polymorphism in the gene promoter is important in the early development of serious complications of the disease.
|
18619044 |
2008 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
CTD_human |
However, it remained uncertain how cigarette smoke induced MMP-9 and how simvastatin inhibited cigarette smoke-induced MMP-9 expression in alveolar macrophages (AMs), a major source of MMP-9 in the lungs of COPD patients.
|
19299917 |
2009 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Inappropriate elevation of matrix metalloproteinase-9 (MMP9) is reported to be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD).
|
19376817 |
2009 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Combinations of genetic variants including *2A homozygotes of CYP1A1 and T alleles in MMP-9 are significant indicators for susceptibility to COPD.
|
19507017 |
2009 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that the MMP-9 -1562C-->T polymorphism could be used as a marker for determining the genetic susceptibility to COPD in a Korean population.
|
20160424 |
2010 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The up-regulation of MMP1 and MMP9 was the main change associated with COPD.
|
20970515 |
2011 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
MMP-9 (gelatinase B) is recognized in chronic obstructive pulmonary disease (COPD) and now asthma as playing a central role in matrix degradation in injury, as well as contributing to the remodeling process.
|
21644819 |
2012 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Cutaneous expression of MMP-9 mRNA and proMMP-9 concentrations was increased in exposed skin of COPD patients (p=0.004 and p=0.02, respectively) and was also associated with increased skin elastin degradation (r=0.62, p<0.001 and r=0.47, p=0.01, respectively).
|
22374923 |
2012 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
According to source of controls, significant association of MMP-9 -1562 C/T (additive model: T vs C; OR:1.71, 95% CI: 1.42-2.07; p<0.00001, and dominant model; OR: 1.92; 95% CI: 1.34-2.76; p = 0.0004) with COPD susceptibility was revealed in the subgroup with smoker-based controls.
|
23555986 |
2013 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
TLR2 levels were increased with ageing, while sputum neutrophils and total sputum MMP-9 levels increased with age, previous smoking, and COPD.
|
23606791 |
2013 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
SIRT1 reduction was associated with imbalance of TIMP-1 and MMP-9 in lungs of smokers and COPD patients.
|
24039251 |
2013 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
On the other hand, subgroup analysis suggested that MMP9 -1562 C/T polymorphism was related to COPD, as we found that C allele carriers were at lower risk in some subgroups stratified by lung function, age and genotype identification method, compared with TT homozygotes.
|
24085258 |
2013 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Moreover, inhibiting Src deterred the cigarette smoke-mediated induction of matrix metalloproteinase-9 and -12 in alveolar macrophages and lung expression of cathepsin K, IL-17, TNF-α, MCP-1, and KC, all key factors in the pathogenesis of COPD.
|
24111605 |
2014 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Serum MMP-9 concentrations were significantly higher in the COPD than in the non-COPD group.
|
25332229 |
2014 |