Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The association of HSP27 with MMP-2 and MMP-9 proteins along with the identified interacting stretch has the potential to contribute towards drug development to inhibit GBM infiltration and migration.
|
31028823 |
2019 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We analysed the transcript expression of CLEC5A in glioblastoma by accessing The Cancer Genome Atlas (TCGA). qRT-PCR was performed to detect the RNA expression of genes in cells and tissues, and Western blot was used to measure the protein levels (Cyclin D1, Bcl-2, BAX, PCNA, MMP2, MMP9, Akt and Akt phosphorylation) in tissues and cells.
|
30834619 |
2019 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Downregulation of the miR-221/222 cluster diminished the invasion, migration, proliferation, and angiogenesis with reduced protein levels of matrix metalloproteinase-2 (MMP-2), MMP-9, and vascular endothelial growth factor in glioblastoma cells.
|
31106423 |
2019 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
TRAF6 correlated to invasion and poor prognosis of glioblastoma via elevating MMP9 expression.
|
30571666 |
2019 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Zymography analysis also revealed that the activities of MMP-2 and MMP-9 of GBM cells were significantly inhibited in response to 100, 200, or 300 μM naringenin treatment.
|
30431227 |
2019 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Glioblastoma xenograft tumors treated with VB showed elevated SHP-1, Bax, cleaved caspase-3, and cleaved PARP expression and reduced p-STAT3, Bcl-2, survivin, MMP-2, and MMP-9 expression. siRNA-SHP-1 inhibited the VB effects on glioblastoma.
|
29961065 |
2018 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Activation of PI3K/AKT signaling prevented the suppressive effects of RWDD3 downregulation on glioblastoma cell proliferation and migration, concurrent with increased protein levels of MMP2 and MMP9.
|
29977365 |
2018 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Voxel-based statistical analysis revealed the anatomical specificity of MMP-9 expression levels in glioblastoma.
|
29187298 |
2018 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results obtained in the present study signified the importance of some genes, such as COL3A1, FN1, and MMP9, for glioblastoma.
|
28191466 |
2017 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Luteolin treatment significantly inhibited glioblastoma cell migration, and this effect was associated with downregulated matrix metalloproteinase (MMP)-2, MMP-9 and upregulated tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2.
|
28927111 |
2017 |
Glioblastoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Phospho-c-Jun activation by Anisomycin treatment in primary glioblastoma-derived cells attenuates the aggressive features of mesenchymal glioblastomas and leads to promoter methylation and downregulation of key mesenchymal genes (CD44, MMP9 and CHI3L1).
|
28036297 |
2017 |
Glioblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the roles of these in the regulation of MMP-2 and MMP-9 in human glioblastoma T-98G cells.
|
28112361 |
2017 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These experimental data suggested that the overexpression of MMP9 in glioblastoma cells may occur primarily through an increase in gene copy number.
|
28454256 |
2017 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Finally, MMP-9 induction facilitated abnormal proliferation, migration, and invasion of cells, which contributed to GBM metastasis.
|
29029486 |
2017 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The expression of EGFR and MMP9 was upregulated in glioblastoma tissues compared to their normal tissues.
|
27621042 |
2016 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, ATO significantly increased adhesion of U87MG cells and also diminished transcription of NF-κB down-stream targets involved in cell migration and invasion, including cathepsin B, uPA, MMP-2, MMP-9 and MMP-14 and suppressed proteolytic activity of cathepsin B, MMP-2 and MMP-9, demonstrating a possible mechanism of ATO effect on a well-known signaling in glioblastoma dissemination.
|
27039805 |
2016 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We profiled the immune-related gene set and identified 8 genes (FOXO3, IL6, IL10, ZBTB16, CCL18, AIMP1, FCGR2B, and MMP9) with the greatest prognostic value in GBM.
|
27225222 |
2016 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results demonstrate that miRNA-146a acts as a novel regulator to modulate the activity and transduction of TGF-β signaling pathways in glioblastoma, and the downregulation of miRNA-146a is required for overexpression of EGFR and MMP9, which can be considered an efficiently therapeutic target and a better understanding of glioblastoma pathogenesis.
|
25326894 |
2015 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these findings suggest that EGFR signaling activates downstream PI3K/Akt to increase MMP9 expression in glioblastoma, while phosphorylation of Akt is a control point by miRNA-181c.
|
24867100 |
2014 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A significant decline of MMP-9 and MMP-2 secretion in cultured U87MG was detected after incubation with EBB (42.9% and 73.0%, respectively) and EBB + TMZ (38.4% and 68.5%, respectively).
|
25256634 |
2014 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings suggest that EGF/EGFR signaling activates downstream PI-3 K/Akt to induce FoxO1 nuclear exclusion, which activates MMP9 to promote glioblastoma invasiveness.
|
24771221 |
2014 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results point out that the bicistronic construct, which can simultaneously silence both MMP-9 and uPAR offers a great therapeutic potential and is worth developing as a new drug for treating GBM patients.
|
23076139 |
2013 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Further research into the underlying mechanism demonstrated that the effects of miR-125b on the invasion of glioblastoma CD133-positive cells were associated with the alteration of the expression of MMPs (MMP-2 and MMP-9) and corresponding inhibitors (RECK and TIMP3).
|
22711523 |
2012 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
MMP-9 and CD44 co-localization on the cell surface was observed in the histological sections of human glioblastoma (GBM) tissues.
|
22024282 |
2012 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Identification of MMP-9 specific microRNA expression profile as potential targets of anti-invasion therapy in glioblastoma multiforme.
|
21831363 |
2011 |