Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Amentoflavone significantly inhibits tumor growth and reduces protein levels of phospho-extracellular signal-regulated kinase (P-ERK), nuclear factor-kappaB (NF-κB) p65 (Ser536), vascular endothelial growth factor (VEGF), matrix metallopeptidase 9 (MMP-9), X-linked inhibitor of apoptosis protein (XIAP), and cyclin-D1 in osteosarcoma in vivo.
|
31262893 |
2019 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, it altered the expression of various proteins associated with cell growth (Ki67, p21, cyclin A, cyclin E, and cyclin-dependent kinase 2), migration (matrix metalloproteinase-2 [MMP-2], MMP-9, and tissue inhibitor of metalloproteinase-1), apoptosis (poly[ADP-ribose] polymerase 1 and caspase 3), and drug resistance (p-glycoprotein 1, lung resistance-related protein 1, growth arrest and DNA damage-45α, glutathione S-transferase π, and heat shock protein 27) in paclitaxel-resistant osteosarcoma cells.
|
31106479 |
2019 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MicroRNA-29b sensitizes osteosarcoma cells to doxorubicin by targeting matrix metalloproteinase 9 (MMP-9) in osteosarcoma.
|
30840264 |
2019 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results of meta-analysis indicated that MMP-9 may be a prognostic biomarker guiding the clinical therapy for OS.
|
30383677 |
2018 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
After SOX4 gene silencing, the protein expression levels of Bax, Caspase-3, and P53 in osteosarcoma cells were significantly elevated, while the protein expression levels of Bcl-2, MMP2, and MMP9 were obviously decreased.
|
29038881 |
2018 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, 14‑3‑3β knockdown significantly decreased the protein expression levels of β‑catenin, cyclin D1, v‑myc avian myelocytomatosis viral oncogene homolog and matrix metallopeptidase 9 in osteosarcoma MG63 cells.
|
29207109 |
2018 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Next, we used lentivector packaging method to overexpress MMP-9 and found that overexpression of MMP-9 promoted OS cell migration.
|
29068478 |
2018 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Suppression of miR-506-3p in osteosarcoma led to increased expression of RAB3D, which in turn led to increased CDK4 (cyclin-dependent kinase 4) and MMP9 (matrix metalloprotein 9) activities.
|
29905536 |
2018 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A reporter gene assay demonstrated that BITC, PEITC, and SFN suppressed TAP-induced MMP-9 expression by inhibiting AP-1 and NF-κB in U20S osteosarcoma cells.
|
28969043 |
2017 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
High levels of CUL1 promote osteosarcoma progression via up-regulation of MMP9 expression.
|
28315506 |
2017 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the prognostic value of MMP-9 on survival of osteosarcoma patients still needs further large-scale trials to be clarified.
|
26239566 |
2017 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taking in account that β1 Integrin and MMP-9 and -13 have been correlated with the invasiveness of osteosarcoma, considering that NCPA affects the invasiveness of 143B cell line, we suggest that this molecule could affect the osteosarcoma metastatic ability.
|
27931795 |
2017 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Notably, MMP‑9 and NF‑κB expression were downregulated by treatment with AbBmi‑1 in MG‑63 osteosarcoma cells.
|
28983587 |
2017 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found a pronounced suppressive effect of glucosamine sulfate particularly on MMP-3 and also MMP-9 mRNA and protein levels in osteosarcoma cell lines in vitro.
|
27562075 |
2016 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We conclude that CD151 knockdown inhibits the expression of MMP9 through the GSK-3β/β‑catenin pathway and also inhibits OS migration and invasion in vitro and metastasis in vivo in highly metastatic OS.
|
26707073 |
2016 |
Osteosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We used bioinformatics tools to identify possible binding sites of miR-491 in the 3'UTR of MMP9 and 30 OS tissue samples were collected and divided into two groups based on the rs1056629 genotype (AA, N=20; AC, N=8; and CC N=2).
|
27023472 |
2016 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A shift from MMP9 to predominant MMP2 activity is associated with poor response to chemotherapy suggesting that the ratio of MMP2/MMP9 activity might be a valuable and easily accessible marker to predict the response to chemotherapy in osteosarcoma.
|
26979530 |
2016 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using tumor tissue microarrays, we analyzed the expression of CXCR4 and MMP9 among 34 primary osteosarcomas with pulmonary metastasis and 62 primary osteosarcomas without metastasis.
|
26546437 |
2016 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of PREX2a also markedly suppressed the invasion and migration of OS cells, at least partly by suppressing the protein expression of matrix metalloproteinase (MMP)2 and MMP9.
|
26718453 |
2016 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Metformin suppressed OS MG63 cell proliferation in a dose- and time-dependent manner and markedly blocked anti-metastatic potentials, migration, and invasion, by downregulating matrix metalloproteinase 2 (MMP2) and MMP9.
|
26164004 |
2015 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vitro and in vivo experiments demonstrated that knockdown of HOTAIR could notably suppress cellular proliferation, inhibit invasion and decrease the secretion of MMP2 and MMP9 in osteosarcoma.
|
25728753 |
2015 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, miR-142 inhibited osteosarcoma cell invasion by inducing E-cadherin expression and reducing expression of matrix metalloproteinase 2 (MMP2) and MMP9.
|
25530132 |
2015 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggested that HEY1 augmented the metastasis of osteosarcoma via upregulation of MMP9 expression.
|
25742474 |
2015 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we determine the functional relevance of Beclin-1 knockdown to osteosarcoma cell growth, migration, and invasion, and investigate the expression levels of matrix metallopeptidase-2 (MMP-2), MMP-9, phosphoinositide 3-kinase p85α (PI3Kp85α), and phosphorylated AKT (p-AKT).
|
25427639 |
2015 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This downregulation of RECK in advanced grades of osteosarcoma and metastatic grades was also associated with the increased expression of invadosome-specific markers like MMP9, phospho-FAK, and integrins, suggesting the complex contributions of RECK in the prevention of metastasis and its downregulation as a causative factor in osteosarcoma metastasis.
|
26130413 |
2015 |