|
melanoma
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Our data showed an increased risk of melanoma (odds ratio [OR] 1.27, 95% confidence interval [95% CI] 1.03-1.57) in carriers of the rs4911414 variant, located 120 kb upstream of ASIP.
|
22628150 |
2013 |
|
melanoma
|
0.380 |
Biomarker
|
disease |
BEFREE |
Few high penetrance genes are known in Malignant Melanoma (MM), however, the involvement of low-penetrance genes such as MC1R, OCA2, ASIP, SLC45A2 and TYR has been observed.
|
23537197 |
2013 |
|
melanoma
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Eight loci were identified in the main meta-analyses as being associated with a risk of CM (P < .05) of which four loci showed a genome-wide statistically significant association (P < 1 × 10(-7)), including 16q24.3 (MC1R), 20q11.22 (MYH7B/PIGU/ASIP), 11q14.3 (TYR), and 5p13.2 (SLC45A2).
|
21693730 |
2011 |
|
melanoma
|
0.380 |
Biomarker
|
disease |
CTD_human |
In this discovery phase, we confirm several previously characterized melanoma-associated loci at MC1R, ASIP and MTAP-CDKN2A.
|
21983785 |
2011 |
|
melanoma
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
The haplotype near ASIP (rs4911414[T] and rs1015362[G]) was significantly associated with fair skin color (OR, 2.28; 95% CI, 1.46-3.57) as well as the risks of melanoma (OR, 1.68; 95% CI, 1.18-2.39) and SCC (OR, 1.54; 95% CI, 1.08-2.19).
|
19384953 |
2009 |
|
melanoma
|
0.380 |
Biomarker
|
disease |
CTD_human |
A haplotype near ASIP, known to affect a similar spectrum of pigmentation traits as MC1R variants, conferred significant risk of CM (odds ratio (OR) = 1.45, P = 1.2 x 10(-9)) and BCC (OR = 1.33, P = 1.2 x 10(-6)).
|
18488027 |
2008 |
|
melanoma
|
0.380 |
GeneticVariation
|
disease |
LHGDN |
A haplotype near ASIP, known to affect a similar spectrum of pigmentation traits as MC1R variants, conferred significant risk of CM (odds ratio (OR) = 1.45, P = 1.2 x 10(-9)) and BCC (OR = 1.33, P = 1.2 x 10(-6)).
|
18488027 |
2008 |
|
melanoma
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
A haplotype near ASIP, known to affect a similar spectrum of pigmentation traits as MC1R variants, conferred significant risk of CM (odds ratio (OR) = 1.45, P = 1.2 x 10(-9)) and BCC (OR = 1.33, P = 1.2 x 10(-6)).
|
18488027 |
2008 |
|
melanoma
|
0.380 |
Biomarker
|
disease |
CTD_human |
Gray horses carrying a loss-of-function mutation in ASIP (agouti signaling protein) had a higher incidence of melanoma, implying that increased melanocortin-1 receptor signaling promotes melanoma development in Gray horses.
|
18641652 |
2008 |
|
melanoma
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Gray horses carrying a loss-of-function mutation in ASIP (agouti signaling protein) had a higher incidence of melanoma, implying that increased melanocortin-1 receptor signaling promotes melanoma development in Gray horses.
|
18641652 |
2008 |
|
melanoma
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
We examined MC1R and ASIP genotypes in relation to phenotypic characteristics, sporadic and familial melanoma risk, and melanoma thickness as an indicator of disease progression in a Mediterranean population.
|
15998953 |
2005 |
|
melanoma
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
We sought to characterize the agouti signaling protein gene (ASIP) in a group of white subjects, to assess whether ASIP was a determinant of human pigmentation and whether this gene may be associated with increased melanoma risk.
|
11833005 |
2002 |
|
Carcinoma, Basal Cell
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
The OCA2 Arg419Gln and ASIP g.8818 A>G were associated with BCC risk (OR, 1.50; 95% CI, 1.06-2.13 and OR, 0.73; 95% CI, 0.53-1.00, respectively).
|
19384953 |
2009 |
|
Carcinoma, Basal Cell
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
A haplotype near ASIP, known to affect a similar spectrum of pigmentation traits as MC1R variants, conferred significant risk of CM (odds ratio (OR) = 1.45, P = 1.2 x 10(-9)) and BCC (OR = 1.33, P = 1.2 x 10(-6)).
|
18488027 |
2008 |
|
Carcinoma, Basal Cell
|
0.320 |
Biomarker
|
disease |
CTD_human |
A haplotype near ASIP, known to affect a similar spectrum of pigmentation traits as MC1R variants, conferred significant risk of CM (odds ratio (OR) = 1.45, P = 1.2 x 10(-9)) and BCC (OR = 1.33, P = 1.2 x 10(-6)).
|
18488027 |
2008 |
|
Malignant neoplasm of skin
|
0.310 |
Biomarker
|
disease |
BEFREE |
We evaluated the associations between 15 SNPs in 8 candidate pigmentation genes (TYR, TYRP1, OCA2, SLC24A5, SLC45A2, POMC, ASIP and ATRN) and both pigmentary phenotypes (hair color, skin color and tanning ability) and skin cancer risk in a nested case-control study of Caucasians within the Nurses' Health Study (NHS) among 218 melanoma cases, 285 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases and 870 common controls.
|
19384953 |
2009 |
|
Malignant neoplasm of skin
|
0.310 |
Biomarker
|
disease |
CTD_human |
ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma.
|
18488027 |
2008 |
|
Skin Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma.
|
18488027 |
2008 |
|
Pigmented Basal Cell Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma.
|
18488027 |
2008 |
|
Obesity
|
0.230 |
Biomarker
|
disease |
BEFREE |
Agouti signaling protein (ASP) is a secreted paracrine protein that has been widely reported to function in melanogenesis and obesity and could potentially be a core protein that regulates the color and fatty phenotype of P. sinensis.
|
31794826 |
2019 |
|
Obesity
|
0.230 |
Biomarker
|
disease |
CTD_mouse |
Impact of obesity on 7,12-dimethylbenz[a]anthracene-induced altered ovarian connexin gap junction proteins in female mice.
|
25447408 |
2015 |
|
Obesity
|
0.230 |
Biomarker
|
disease |
CTD_mouse |
Enhanced susceptibility of ovaries from obese mice to 7,12-dimethylbenz[a]anthracene-induced DNA damage.
|
25448685 |
2014 |
|
Obesity
|
0.230 |
Biomarker
|
disease |
MGD |
Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice.
|
18172198 |
2008 |
|
Obesity
|
0.230 |
Biomarker
|
disease |
MGD |
Germ-line epigenetic modification of the murine A vy allele by nutritional supplementation.
|
17101998 |
2006 |
|
Obesity
|
0.230 |
AlteredExpression
|
disease |
BEFREE |
Mahoganoid effects on energy homeostasis are, therefore, most evident in the circumstances of epistasis to hypothalamic overexpression of ASP in A(y) and possible other obesity-causing mutations.
|
12438443 |
2002 |