|
Acute pancreatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increase in α-smooth muscle actin and nestin-positive stellate cell numbers in acute pancreatitis was correlated to increase in numbers of CD34-positive vascular endothelium, CD68- or CD163-positive macrophages, CD138-positive plasmacytes, CD3-positive T lymphocytes, and myeloperoxidase-positive leucocytes.
|
31688596 |
2020 |
|
Acute pancreatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Compared to CLT solution and the NPs/CLT group, NNPs/CLT significantly downregulated the levels of serum amylase and pancreatic myeloperoxidase in AP rats.
|
30753778 |
2019 |
|
Acute pancreatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Butyrate prophylaxis attenuated AP as shown by reduced serum amylase and lipase levels, pancreatic oedema, myeloperoxidase activity, and improved pancreatic morphology.
|
31347703 |
2019 |
|
Acute pancreatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CM4620 also decreased myeloperoxidase activity and inflammatory cytokine expression in pancreas and lung tissues, fMLF peptide-induced oxidative burst in human neutrophils, and cytokine production in human peripheral blood mononuclear cells (PBMCs) and rodent PaSCs, indicating that Orai1/STIM1 channels participate in the inflammatory responses of these cell types during acute pancreatitis.
|
31050811 |
2019 |
|
Acute pancreatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, over-expression of miR-148a improved the pathological state of AP through H&E and MPO staining and transmission electron microscopy.
|
31122822 |
2019 |
|
Acute pancreatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Compared with the AP group, after treatment with alprostadil, AG490, and alprostadil+AG490, respectively, the pancreatic pathological score, apoptosis, MDA, MPO, serum IL-1ß, IL-6, and TNF-alpha were significantly decreased in AP rats, while SOD levels were significantly increased.
|
31606729 |
2019 |
|
Acute pancreatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Administration of menadione attenuated the severity of AP and associated lung injury as shown by the histopathology, reduced MPO and serum amylase activity.
|
30685119 |
2019 |
|
Acute pancreatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Plasma levels of amylase and lipase, pancreatic myeloperoxidase (MPO), histology, visceral hypernociception and motor coordination were evaluated 11 and 24 h after acute pancreatitis (AP) induction.
|
30119202 |
2018 |
|
Acute pancreatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our findings indicated that the CRP, PTX-3, MPO and PCT levels increase in patients with AP and hence these indicators can be used as diagnostic factors to predict inflammation severity in AP.
|
29593801 |
2018 |
|
Acute pancreatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
ALR decreased the MPO activity of pancreas in AP Mice.
|
29511434 |
2018 |
|
Acute pancreatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The severity of AP was assessed by histological grading, proinflammatory cytokine levels, biochemistry, myeloperoxidase (MPO) activity, and analysis of JAK/STAT3 activity.
|
29328945 |
2018 |
|
Acute pancreatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Administration of SC attenuated the severity of AP and associated lung injury as shown by histology, reduced myeloperoxidase, and serum amylase activity.
|
29595543 |
2018 |
|
Acute pancreatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mean lung field occupancy was significantly different between moderate and severe CER-AP (21.9% v 27.5%, p < 0.05) and corresponded with lung MPO and local injury severity parameters and was mirrored for all models tested.
|
29784598 |
2018 |
|
Acute pancreatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TLCS-AP, FAEE-AP and CER-AP resulted in characteristic elevations in serum amylase and cytokine levels, increased pancreatic trypsin and myeloperoxidase activity, typical pancreatic histopathological changes and lung injury.
|
28648518 |
2018 |
|
Acute pancreatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Increased levels of MDA, NO, and expression of myeloperoxidase and nitrotyrosine in the parameters estimated add evidence to the role of oxidative stress and inflammation in acute pancreatitis.
|
30307087 |
2018 |
|
Acute pancreatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Tropisetron significantly attenuated pancreatic injury markers and decreased the amount of elevated serum amylase, lipase, alanine aminotransferase (ALT), aspartate aminotransferase (AST), MPO activities and pro-inflammatory cytokines levels caused by AP in mice.
|
28686973 |
2017 |
|
Acute pancreatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In both tissues of male and female AP groups MPO, MDA, SOD levels were increased (P < 0.05 - 0.01) and GSH levels were decreased (P < 0.05).
|
29550797 |
2017 |
|
Acute pancreatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, MPO was down-regulated and SOD was up-regulated in the MS treated pancreas, indicating that MS had an anti-oxidant effect against AP.
|
28759809 |
2017 |
|
Acute pancreatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found that LMP supplementation attenuated the severity of AP as evidenced by reduced serum amylase and lipase levels, pancreatic edema and myeloperoxidase activity.
|
27921358 |
2017 |
|
Acute pancreatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Administration of AA significantly reduced the severity of AP, and was associated with reduction of serum amylase and lipase levels, decreased pancreatic histological damage, and decreased myeloperoxidase activity.
|
28861174 |
2017 |
|
Acute pancreatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, infiltration of leukocytes and MPO activity in the lungs and pancreas during acute pancreatitis was decreased in S100A9-deficient mice and associated with significantly lower serum amylase and lipase activities as well as reduced intrapancreatic TAP-levels.
|
18452188 |
2008 |