|
Glomerulonephritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These observations suggest that the activation of granulocytes and local MPO release contribute to the pathogenesis of GN and vasculitis.
|
31476889 |
2020 |
|
Glomerulonephritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Myeloperoxidase ANCA is more common than proteinase-3 ANCA, and glomerulonephritis is the most common clinical presentation of ANCA-associated vasculitis in SSc.
|
31776158 |
2019 |
|
Glomerulonephritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In late autoimmunity, Th1 deficient mice developed reduced autoimmunity and were protected from anti-myeloperoxidase glomerulonephritis.
|
31443998 |
2019 |
|
Glomerulonephritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The ratio between PR3-ANCA and MPO-ANCA varies in glomerulonephritis with respect to age, gender, renal function and geographic latitude/UV radiation levels.
|
29718465 |
2019 |
|
Glomerulonephritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mice immunized with 6PGD<sub>391-410</sub>, or with S. aureus containing a plasmid expressing 6PGD<sub>391-410</sub>, develop glomerulonephritis when MPO is deposited in glomeruli.
|
31358739 |
2019 |
|
Glomerulonephritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The C3aR promotes macrophage infiltration and regulates ANCA production but does not affect glomerular injury in experimental anti-myeloperoxidase glomerulonephritis.
|
29315316 |
2018 |
|
Glomerulonephritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clinical and pathological characteristics from 20 kidney biopsy-proven pauci-immune anti-myeloperoxidase antibody-associated GN patients with nephrotic proteinuria were analyzed and were compared with ANCA GN patients without nephrotic proteinuria.
|
30278797 |
2018 |
|
Glomerulonephritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report two patients diagnosed with anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis with MN-lesions, in whom ANCA titers for myeloperoxidase (MPO) were persistently positive.
|
29792176 |
2018 |
|
Glomerulonephritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additionally, given the presence of the myeloperoxidase antibody and glomerulonephritis on renal biopsy, our patient was diagnosed with microscopic polyangiitis (MPA).
|
30131924 |
2018 |
|
Glomerulonephritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study highlights the importance of oxidative defenses to counteract the process of MPO-ANCA associated glomerulonephritis.
|
30207165 |
2018 |
|
Glomerulonephritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These changes are mediated by C5aR1 on dendritic cells, which promotes activation, and thus myeloperoxidase autoimmunity and glomerulonephritis.
|
29241626 |
2018 |
|
Glomerulonephritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we studied the effects of EDO-S101 in two established rodent models of ANCA-associated vasculitis: a passive mouse model of anti-myeloperoxidase IgG-induced glomerulonephritis and an active rat model of myeloperoxidase-ANCA microscopic polyangiitis.
|
30158055 |
2018 |
|
Glomerulonephritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Monocytes Promote Crescent Formation in Anti-Myeloperoxidase Antibody-Induced Glomerulonephritis.
|
28667835 |
2017 |
|
Glomerulonephritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Studies in <i>δTCR</i><sup>-/-</sup> and transfer of γδ T cells to <i>δTCR</i><sup>-/-</sup> mice show that γδ T cells facilitate the generation of anti-MPO autoimmunity and GN.
|
28954887 |
2017 |
|
Glomerulonephritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This dual role of the mast cells is evident in myeloperoxidase anti-neutrophil cytoplasmic antibodies-mouse model of glomerulonephritis in which mast cell deficiency worsens glomerulonephritis, whereas inhibition of mast cell degranulation is effective in abrogating the development of glomerulonephritis.
|
28878769 |
2017 |
|
Glomerulonephritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Age-determined severity of anti-myeloperoxidase autoantibody-mediated glomerulonephritis in mice.
|
28186568 |
2017 |
|
Glomerulonephritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
ANCA to either PR3 or MPO are found in patients with necrotizing vasculitis and glomerulonephritis.
|
27365530 |
2016 |
|
Glomerulonephritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clinical significance of serum and urinary soluble urokinase receptor (suPAR) in primary nephrotic syndrome and MPO-ANCA-associated glomerulonephritis in Japanese.
|
25500737 |
2015 |
|
Glomerulonephritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both in vitro and in vivo experimental data have shown that MPO-ANCA can induce necrotizing small-vessel vasculitis and glomerulonephritis.
|
23810690 |
2013 |
|
Glomerulonephritis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Functional polymorphism of the myeloperoxidase gene in hypertensive nephrosclerosis dialysis patients.
|
18344624 |
2007 |
|
Glomerulonephritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
When MPO-deficient mice are, however, immunised with murine MPO, anti-MPO immunoglobulins are purified and subsequently injected into mice that are not deficient for MPO, systemic vasculitis and glomerulonephritis is induced.
|
15025415 |
2003 |