|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this retrospective cohort study, we analyzed consecutive patients with myeloperoxidase-antineutrophil cytoplasmic antibody-positive MPA who had undergone chest computed tomography (CT) before starting treatment between 2006 and 2016.
|
30929541 |
2020 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thirty-four (60%) patients had AAGN.Of these, 65% had microscopic polyangiitis (MPA) and 74% were myeloperoxidase (MPO)-ANCA positive.
|
30102330 |
2019 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
MPO-ANCA positive GPA patients were likely to have relapse than MPO-ANCA positive MPA patients.
|
29887327 |
2019 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
For Chinese patients suspected of having GPA and MPA, both the first-generation enzyme-linked immunosorbent assay (ELISA) and high-quality antigen-specific immunoassay can be used to detect MPO-ANCA and PR3-ANCA alone, without the combined detection with IIF to have good diagnostic performance.
|
31414304 |
2019 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, outcomes of these studies are not easy to compare.<b>Expert opinion</b>: Regardless of the treatment used, patients presenting with an anti-proteinase-3 ANCA, relapsing GPA have a substantially higher risk of relapse compared to patients with newly diagnosed MPA or positive anti-myeloperoxidase ANCA.
|
31762340 |
2019 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We present a case of thymoma-associated microscopic polyangiitis with positivity for three ANCAs: MPO-ANCA, PR3-ANCA and azurocidin-ANCA.
|
30961527 |
2019 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study was conducted retrospectively at Caen University Hospital and included all consecutive granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) patients with positive proteinase 3-ANCA or myeloperoxidase-ANCA, from January 2000 or September 2011, respectively, to June 2016.
|
30824651 |
2019 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Similarly, the prognosis was identical between anti-MPO MPA patients and anti-PR3 MPA patients (P = 0.33, 0.19 and 0.65, respectively), and between anti-MPO GPA patients and anti-PR3 GPA patients (P = 0.06, 0.99 and 0.64, respectively).
|
30805643 |
2019 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among the 93 patients (76 with MPA and 17 with GPA), only 6 patients developed HP (1 with MPA, 5 with GPA) over an average observation period of 4 years; all patients who developed HP were positive for myeloperoxidase anti-neutrophil antibody.
|
30483978 |
2019 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additionally, given the presence of the myeloperoxidase antibody and glomerulonephritis on renal biopsy, our patient was diagnosed with microscopic polyangiitis (MPA).
|
30131924 |
2018 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
ANCA are usually of anti-MPO specificity and microscopic polyangiitis is the most frequent vasculitis.
|
30404113 |
2018 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Glomerulonephritis is a severe complication of microscopic polyangiitis (MPA), a small-vessel vasculitis associated with anti-myeloperoxidase antibodies (MPO-ANCA).
|
30207165 |
2018 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The small vessel vasculitides granulomatosis with polyangiitis (GPA) and microscopic polyangiitis are associated with autoantibodies to neutrophil cytoplasm antigens (ANCA), principally proteinase-3 (PR3) and myeloperoxidase (MPO).
|
29447930 |
2018 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-neutrophil cytoplasmic antibody-associated glomerulonephritis with detection of myeloperoxidase and phospholipase A<sub>2</sub> receptor in membranous nephropathy-lesions: report of two patients with microscopic polyangiitis.
|
29792176 |
2018 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we studied the effects of EDO-S101 in two established rodent models of ANCA-associated vasculitis: a passive mouse model of anti-myeloperoxidase IgG-induced glomerulonephritis and an active rat model of myeloperoxidase-ANCA microscopic polyangiitis.
|
30158055 |
2018 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
All 14 enrolled AASV patients had myeloperoxidase (MPO)-positive microscopic polyangiitis (MPA).
|
29465037 |
2018 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
MPO-ANCA positivity was uncommon, but was associated with subsequent MPA development in patients initially diagnosed with IIP, including both IPF and non-IPF cases.
|
29928060 |
2018 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To evaluate circulating cytokine profiles in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV), classified by antineutrophil cytoplasmic antibody (ANCA) specificity (proteinase 3 ANCA [PR3-ANCA] versus myeloperoxidase ANCA [MPO-ANCA]) or by clinical diagnosis (granulomatosis with polyangiitis [GPA] versus microscopic polyangiitis [MPA]).
|
29693324 |
2018 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Positive Perinuclear Anti-Neutrophil Cytoplasmic Antibodies (P-ANCA) and Myeloperoxidase-ANCA (MPO-ANCA) titres led to a diagnosis of microscopic polyangiitis.
|
30453935 |
2018 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We presented patient who developed MPO-ANCA-associated MPA with lung and musculoskeletal involvement after 4 years on regular HD due to bilateral nephrectomy.
|
28243232 |
2017 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also compared NET formation between MPO-ANCA-positive/negative MPA and rheumatoid arthritis (RA)-associated vasculitic neuropathy.
|
28124760 |
2017 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The association of MPO with HLA-DR was analyzed using MPO and HLA-DR transfectants as well as neutrophils from healthy donors and patients with MPA.
|
28575531 |
2017 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order to provide an update on the recent advances in the pathogenesis, clinical features and novel treatments of lung involvement in systemic vasculitis, a systematic MedLine search has been performed.Most of the data analyzed have confirmed that lung involvement seems to develop more frequently in patients with myeloperoxidase-ANCA-positive AAV, mainly in those with a diagnosis of microscopic polyangiitis (MPA), compared with patients with proteinase 3 ANCA-positive AAV.
|
27755177 |
2017 |
|
Microscopic Polyarteritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We reviewed the medical records of 133 patients with microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) and eosinophilic GPA (EGPA), who had either myeloperoxidase (MPO)-ANCA, proteinase 3 (PR3)-ANCA or no ANCA, and who had ever achieved the first remission.
|
28339364 |
2017 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Protective Role of HLA-DRB1*13:02 against Microscopic Polyangiitis and MPO-ANCA-Positive Vasculitides in a Japanese Population: A Case-Control Study.
|
27166610 |
2016 |