|
Granulomatosis with polyangiitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
There is a difference in mean age at onset and proteinase 3 (PR3) or myeloperoxidase (MPO) positivity in GPA patients from different Asian countries.
|
30338654 |
2019 |
|
Granulomatosis with polyangiitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among the 93 patients (76 with MPA and 17 with GPA), only 6 patients developed HP (1 with MPA, 5 with GPA) over an average observation period of 4 years; all patients who developed HP were positive for myeloperoxidase anti-neutrophil antibody.
|
30483978 |
2019 |
|
Granulomatosis with polyangiitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Similarly, the prognosis was identical between anti-MPO MPA patients and anti-PR3 MPA patients (P = 0.33, 0.19 and 0.65, respectively), and between anti-MPO GPA patients and anti-PR3 GPA patients (P = 0.06, 0.99 and 0.64, respectively).
|
30805643 |
2019 |
|
Granulomatosis with polyangiitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Minimal to mild CS predicted recovery of renal function at 1 year; clinical diagnosis (granulomatosis with polyangiitis versus MPA) and ANCA specificity (proteinase 3 versus MPO) did not.
|
30102330 |
2019 |
|
Granulomatosis with polyangiitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
There is some evidence that MPO ANCA positive GPA disease may be 'limited' in its expression and be associated with the more indolent phenotype.
|
29611345 |
2019 |
|
Granulomatosis with polyangiitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
MPO-ANCA positive GPA patients were likely to have relapse than MPO-ANCA positive MPA patients.
|
29887327 |
2019 |
|
Granulomatosis with polyangiitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study was conducted retrospectively at Caen University Hospital and included all consecutive granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) patients with positive proteinase 3-ANCA or myeloperoxidase-ANCA, from January 2000 or September 2011, respectively, to June 2016.
|
30824651 |
2019 |
|
Granulomatosis with polyangiitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aortitis and pachymeningitis: an unusual combination in granulomatosis with polyangiitis (myeloperoxidase-associated vasculitis).
|
30696638 |
2019 |
|
Granulomatosis with polyangiitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Anti-neutrophil cytoplasmic autoantibodies (ANCA) targeting proteinase 3 (PR3) and myeloperoxidase expressed by innate immune cells (neutrophils and monocytes) are salient diagnostic and pathogenic features of small vessel vasculitis, comprising granulomatosis with polyangiitis (GPA), microscopic polyangiitis, and eosinophilic GPA.
|
29686675 |
2018 |
|
Granulomatosis with polyangiitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To evaluate circulating cytokine profiles in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV), classified by antineutrophil cytoplasmic antibody (ANCA) specificity (proteinase 3 ANCA [PR3-ANCA] versus myeloperoxidase ANCA [MPO-ANCA]) or by clinical diagnosis (granulomatosis with polyangiitis [GPA] versus microscopic polyangiitis [MPA]).
|
29693324 |
2018 |
|
Granulomatosis with polyangiitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The small vessel vasculitides granulomatosis with polyangiitis (GPA) and microscopic polyangiitis are associated with autoantibodies to neutrophil cytoplasm antigens (ANCA), principally proteinase-3 (PR3) and myeloperoxidase (MPO).
|
29447930 |
2018 |
|
Granulomatosis with polyangiitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, several genetic loci of S. aureus are associated with either PR3-ANCA- or MPO-ANCA-positive AAV, indicating a possible role for pore-forming toxins, such as leukocidins, in PR3-ANCA-positive GPA.
|
28939882 |
2017 |
|
Granulomatosis with polyangiitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Meanwhile, initial BVAS or BVAS for GPA ≥13.5 in MPO-ANCA vasculitis and initial FFS (1996) ≥1 in MPO-ANCA and ANCA-negative vasculitis were significant predictors of relapse of each AAV category.
|
28339364 |
2017 |
|
Granulomatosis with polyangiitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chronic hypertrophic pachymeninigitis occurs in anti-proteinase 3-positive patients with systemic GPA and in anti-myeloperoxidase-positive patients with a milder and more limited form of the disease.
|
29061243 |
2017 |
|
Granulomatosis with polyangiitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV), granulomatosis with polyangiitis (GPA) and proteinase 3-ANCA-positive AAV (PR3-AAV) are prevalent in European populations, while microscopic polyangiitis (MPA) and myeloperoxidase-ANCA-positive AAV (MPO-AAV) are predominant in the Japanese.
|
27166610 |
2016 |
|
Granulomatosis with polyangiitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A collaborative international study comparing the epidemiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis between Japan and the United Kingdom (UK) demonstrated that microscopic polyangiitis and myeloperoxidase-ANCA were more common in Japan, whereas granulomatosis with polyangiitis and pronase 3-ANCA were more common in the UK.
|
23715862 |
2013 |
|
Granulomatosis with polyangiitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients with AAV (n=105) subgrouped as microscopic polyangiitis or granulomatosis with polyangiitis (Wegener's granulomatosis) and myeloperoxidase (MPO) or proteinase 3 (PR3) ANCA positive were compared to a control group of 200 blood donors.
|
24356554 |
2013 |
|
Granulomatosis with polyangiitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The distinct associations of PR3-ANCA and MPO-ANCA with different HLA class II antigens, which are stronger than those with the associated diseases, suggest a pathogenic role for those ANCAs and indicate that GPA and MPA are different diseases.
|
23810690 |
2013 |
|
Granulomatosis with polyangiitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Antineutrophil cytoplasmic autoantibodies (ANCA) directed to proteinase 3 (PR3-ANCA) or myeloperoxidase (MPO-ANCA) are closely associated with the idiopathic systemic necrotizing vasculitides, in particular Wegener's granulomatosis, microscopic polyangiitis and its renal limited manifestation, and Churg Strauss Syndrome.
|
12849060 |
2002 |