|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry (IHC) for mismatch repair (MMR) proteins is an established test to identify Lynch syndrome (LS) in patients with colorectal cancer and is being increasingly used to identify LS in women with endometrial and/or nonserous ovarian cancer (OC).
|
30864976 |
2019 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
MMR gene may be a potential prognosis predictor in ovarian cancer.
|
29063235 |
2018 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, 167 of 462 patients (36%) had not registered with a Hereditary Cancer Clinic in NSW/ACT, including 11 women with high-grade serous ovarian cancer and seven women with abnormal MMR immunohistochemistry.
|
27530527 |
2016 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Only 4 cases (12.5%) that had specific MMR protein loss showed the same type of loss for both endometrial and ovarian tumors, in which 3 of the cases were losses in MLH1.
|
25695547 |
2015 |
|
ovarian neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The incidence of germline MMR gene mutations in ovarian cancer is only 2% but other mechanisms of gene inactivation mean that loss of expression of one of the seven main genes (MSH2, MSH3, MSH6, MLH1, MLH3, PMS1 and PMS2) occurs in up to 29% of cases.
|
24333356 |
2014 |
|
ovarian neoplasm
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Studies examining MSI, loss of MMR gene expression by IHC staining and MLH1 promoter hypermethylation in ovarian cancer were identified by a systematic literature search of the PubMed electronic database through August 31, 2009.
|
21140452 |
2011 |
|
ovarian neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this retrospective multicentre study was to describe survival in carriers of pathogenic mutations in one of the MMR genes, and who had contracted ovarian cancer.
|
19635727 |
2010 |
|
ovarian neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No significant correlation was found between the frequency of ovarian cancer and MMR gene mutation status in the families.
|
18972272 |
2008 |
|
ovarian neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Occurrence of childhood tumors in hereditary cancer syndromes such as BRCA1/2 associated breast and ovarian cancer, DNA-mismatch repair (MMR) genes associated hereditary non polyposis colorectal cancer and CDKN2A associated familial malignant melanoma are very little studied.
|
18481196 |
2008 |
|
ovarian neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We performed a large multicentre case-control study to investigate associations of common variations in MMR genes and ovarian cancer using a single nucleotide polymorphism (SNP) tagging approach.
|
16774946 |
2006 |
|
ovarian neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In hereditary nonpolyposis colorectal cancer (HNPCC), women with a mismatch repair (MMR) gene mutation have a cumulative lifetime risk of 25-50% for endometrial cancer and 8-12% for ovarian cancer.
|
14529665 |
2003 |