|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Knockdown of HOXA10 reverses the multidrug resistance of human chronic mylogenous leukemia K562/ADM cells by downregulating P-gp and MRP-1.
|
27035504 |
2016 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found that overexpression of MRP1 occurred in most Iranian pediatric leukemia patients at relapse.
|
22901208 |
2012 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, it had no effect on P-glycoprotein-mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells and multidrug resistance-related protein 1-mediated doxorubicin resistance in MRP1-transfected human epidermoid cancer KB-3-1 cells.
|
21566063 |
2011 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To establish whether MRP1 gene copy number is a common feature of the upregulation of MRP1 expression in cancer patients, we studied the MRP1 gene copy number in leukemia patients by fluorescent in situ hybridization (FISH) and real-time PCR.
|
17350479 |
2007 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine the antitumor effect of arsenic trioxide (As2O3) on multidrug-resistant cells, we applied 3 human leukemia cell lines: daunorubicin (DNR)-resistant cell line K562/D1-9, which overexpresses p-glycoprotein (Pgp); DNR and 1-beta-D-arabinofuranosylcytosine (Ara-C) double-resistant cell line HL60/AD, which overexpresses multidrug resistance-associated protein (MRP1); and Bcl-2-transfected pre-B lineage leukemia cell line 697/Bcl-2.
|
15868938 |
2005 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Multidrug resistance-associated protein 1 (MRP1) can confer drug resistance in vitro and MRP1 may play a role in the development of drug resistance in several cancers including acute myeloid leukaemia, small cell lung cancer, T-cell leukaemia and neuroblastoma.
|
15979785 |
2005 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Pgp activity was higher in CD34+ leukemia than in CD34- leukemia (2.26 +/- 1.50 vs 1.46 +/- 1.21 respectively, p = 0.003) and MRP1 activity was higher in CD34- leukemia than in CD34+ leukemia (1.77 +/- 0.40 vs 1.4 +/- 0.29 respectively, p = 0.004).
|
10500791 |
1999 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Pgp activity was higher in CD34+ leukemia than in CD34- leukemia (2.26 +/- 1.50 v 1.46 +/- 1.21, respectively; P = .003), and MRP activity was higher in CD34- leukemia than in CD34+ leukemia (1.77 +/- 0.40 v 1.4 +/- 0.29, respectively; P = .004).
|
9616142 |
1998 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Amplification and expression of the ABC transporters ARA and MRP in a series of multidrug-resistant leukaemia cell sublines.
|
9649117 |
1998 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Sequential emergence of MRP- and MDR1-gene over-expression as well as MDR1-gene translocation in homoharringtonine-selected K562 human leukemia cell lines.
|
8575859 |
1996 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that hyperexpression of MRP is observed in leukaemias, and that further studies are needed to assess the clinical relevance of MRP.
|
8833393 |
1996 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
DNA analysis by Southern blotting did not reveal amplification of the MRP gene in the leukemia samples, including those with elevated MRP mRNA levels.
|
7911548 |
1994 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Southern blot analysis did not reveal amplification of the MRP gene in the leukaemia samples with elevated MRP mRNA levels.
|
7803281 |
1994 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings provide important insight into the biology of inversion 16 leukaemia and suggest that MRP deletion, as detected by molecular analysis, may have a key role in determining outcome in patients with inversion 16 AML.
|
7911871 |
1994 |