Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
We provide the first evidence that enhanced cytosolic sensing of Ld-DNA in infection by antimony resistant (SBR-LD), but not antimony sensitive L.donovani strains (SBS-LD), was critically regulated by host MDRs, multi drug resistant associated protein 1 (MRP 1) and permeability glycoprotein (P-gp) in macrophages.
|
31285443 |
2019 |
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
Targeting Nucleotide Binding Domain of Multidrug Resistance-associated Protein-1 (MRP1) for the Reversal of Multi Drug Resistance in Cancer.
|
30097643 |
2018 |
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the basis of phylogenetic analysis, domain organization and nomenclature adopted by the Human Genome Organization (HUGO) scheme, these proteins were categorized into six subfamilies such as Pleiotropic Drug Resistance (PDR)/ABCG, Multi Drug Resistance (MDR)/ABCB, Multi Drug Resistance associated Protein (MRP)/ABCC, Adrenoleukodystrophy protein (ALDp)/ABCD, RNase L Inhibitor (RLI)/ABCE and Elongation Factor 3 (EF3)/ABCF.
|
30153284 |
2018 |
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the expression levels of genes involved in apoptosis (PI3 K, AKT, BCL2, BAX, p53, p21, PTEN, CASP3, CASP8, and CASP9), differentiation (PML-RAR and HDAC1), and multi-drug resistance (ABCB1 and ABCC1) were determined using quantitative real-time PCR.
|
28865123 |
2018 |
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, it was found that Ori significantly suppressed DDP-resistant human SGC7901/DDP cell proliferation, growth and colony formation, causing increased caspase-dependent apoptosis, decreased expression of P-glycoprotein (P-gp), encoded by the MDR gene, multi-drug resistance-associated protein (MRP1), and cyclin D1.
|
28781688 |
2017 |
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the drug transporters ABCG2, ABCB1 and ABCC1 have been majorly implicated in cancer drug resistance, recent studies have associated ABCC3 with multi drug resistance and poor clinical response.
|
27171227 |
2016 |
Multiple Chronic Conditions
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Silencing of microRNA-127 also significantly reduced the mRNA and protein expression levels of MDR1 and MRP1, which are major ATP-binding cassette (ABC) transporter linked to multi-drug resistance in cancer cells.
|
26261488 |
2015 |
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
PEITC inhibited cisplatin-resistant human SGC7901/DDP cell growth in a dose-dependent manner, causing increased apoptosis, ROS generation, glutathione depletion, accumulation of Rhodamine-123, decreased expression of P-glycoprotein and cell cycle arrest. mRNA and protein expression of the multi-drug resistance gene (MDR1), multi-drug resistance-associated protein (MRP1), excision repair cross-complementing gene 1 (ERCC1), survivin, and Mad2 was decreased, and phosphorylation of Akt and transcriptional activation of NF-κB were suppressed.
|
23956061 |
2014 |
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that vinorelbine increased drug sensitivity to cisplatin and intracellular accumulation of rhodamine-123, while decreasing expression of P-glycoprotein (P-gp), multi-drug resistance-associated protein (MRP1) and glutathione-S-transferase Π (GST-Π) in A549/DDP cells.
|
24083716 |
2013 |
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
Detection and characterisation of multi-drug resistance protein 1 (MRP-1) in human mitochondria.
|
22353810 |
2012 |
Multiple Chronic Conditions
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PCR data showed that MRP1 was more highly expressed when compared to another ATP-binding cassette family, multi-drug resistant protein and the expression levels of MRP1 on the cells were specifically dose- and time-dependently depleted by the addition of SAL.
|
22083453 |
2012 |
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
The three major candidates accounting for the development of MDR in acute myeloid leukaemia (AML) are multi drug resistance gene (MDR1), multi drug resistance-related protein gene (MRP1) and lung resistance protein gene (LRP).
|
15667534 |
2005 |
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, we measured the mRNA expression of multi drug resistance protein 1 (MDR-1), multi drug resistance related protein 1 (MRP-1) and breast cancer resistance protein (BCRP) by real-time PCR analysis after treatment with AN-215.
|
16322338 |
2005 |
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fresh frozen samples of 45 primary OSCC were investigated for the expression of mdr1 (p-glycoprotein-mediated multi-drug resistance), mrp1 (multi-drug resistance-related protein) and bcrp (breast cancer-related protein), using a reverse transcriptase PCR.
|
15113040 |
2004 |