|
Papillary thyroid carcinoma
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Overall, we found that linc01278 can act as a competing endogenous RNA (ceRNA) to sponge miR-376c-3p, thereby positively regulating DNM3 expression and ultimately acting as a tumor suppressor gene in PTC progression.
|
31572010 |
2019 |
|
Papillary thyroid carcinoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Down-regulation of 14q32-encoded miRNAs and tumor suppressor role for miR-654-3p in papillary thyroid cancer.
|
28030816 |
2017 |
|
Carcinoma, Ovarian Epithelial
|
0.310 |
Biomarker
|
disease |
CTD_human |
Moreover, in serous carcinoma samples taken from ovarian cancer patients who responded well to chemotherapy, strong ALK7 staining and low miR-376c expression was detected.
|
21224400 |
2011 |
|
Carcinoma, Ovarian Epithelial
|
0.310 |
Biomarker
|
disease |
BEFREE |
Taken together, these results demonstrate that the Nodal-ALK7 pathway is involved in cisplatin-induced cell death in ovarian cancer cells and that miR-376c enhances proliferation, survival and chemoresistance by targeting, at least in part, ALK7.
|
21224400 |
2011 |
|
Nonmedullary Thyroid Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Down-regulation of 14q32-encoded miRNAs and tumor suppressor role for miR-654-3p in papillary thyroid cancer.
|
28030816 |
2017 |
|
Familial Nonmedullary Thyroid Cancer
|
0.300 |
Biomarker
|
disease |
CTD_human |
Down-regulation of 14q32-encoded miRNAs and tumor suppressor role for miR-654-3p in papillary thyroid cancer.
|
28030816 |
2017 |
|
Pancreatitis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Identfication of key miRNAs in pancreatitis using bioinformatics analysis of microarray data.
|
27840954 |
2016 |
|
Liver Cirrhosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Plasma microRNA profiles in rat models of hepatocellular injury, cholestasis, and steatosis.
|
22363424 |
2012 |
|
Fibrosis, Liver
|
0.300 |
Biomarker
|
disease |
CTD_human |
Plasma microRNA profiles in rat models of hepatocellular injury, cholestasis, and steatosis.
|
22363424 |
2012 |
|
Cocaine Abuse
|
0.300 |
Biomarker
|
disease |
CTD_human |
Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction.
|
20643829 |
2010 |
|
Cocaine-Related Disorders
|
0.300 |
Biomarker
|
group |
CTD_human |
Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction.
|
20643829 |
2010 |
|
Cocaine Dependence
|
0.300 |
Biomarker
|
disease |
CTD_human |
Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction.
|
20643829 |
2010 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Overexpression of the miR-441, as well as miR-376c, promoted cell viability, migration, and invasion in the human immortalized cytotrophoblast cell line HTR8/SVneo, indicating that their decrease in pregnant women would result in anomalous apoptosis and functional imbalance resulting in premature abortion and other complications.
|
30970081 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
DLX6-AS1 knockdown suppressed cell proliferation, cycle and invasion via regulating miR-376c expression.
|
31814904 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Moreover, knockdown of miR-376c-3p repressed HCC cell growth, migration and invasion <i>in vitro</i>. miR-376c-3p overexpression facilitated these malignant behaviors of Bel-7402 cells.
|
30519319 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Overexpression of GADD45A effectively attenuated a miR-376c-induced increase in the proliferation, migration and invasion of HTR-8/SVneo cells.
|
30055134 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Here, we show that miR-376c, a well-characterized tumor suppressor which inhibits cell proliferation and invasion in osteosarcoma by targeting to transforming growth factor-alpha, suppresses osteoblast proliferation, and differentiation.
|
29125885 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
MiR-376c-3p suppresses the fission, proliferation, migration and invasion and induces cell apoptosis of OSCC via targeting HOXB7.
|
28482289 |
2017 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Taken together, these results indicate that LRH-1 is involved in regulating the growth and invasion of NSCLC cells and that miR-376c inhibits NSCLC cell growth and invasion by targeting LRH-1, providing a novel insight into the potential for development of anti-cancer drugs for NSCLC.
|
27049310 |
2016 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
miR-376c inhibits cervical cancer cell proliferation and invasion by targeting BMI1.
|
27345009 |
2016 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of miR-376c suppressed TGFA expression and the expression of its downstream signaling molecule such as epidermal growth factor receptor, and attenuated cell proliferation and invasion.
|
23631646 |
2013 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results demonstrate that miR-376c inhibits both ALK5 and ALK7 expression to impair transforming growth factor-β/Nodal signaling, leading to increases in cell proliferation and invasion.
|
23424236 |
2013 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Here, we show that miR-376c, a well-characterized tumor suppressor which inhibits cell proliferation and invasion in osteosarcoma by targeting to transforming growth factor-alpha, suppresses osteoblast proliferation, and differentiation.
|
29125885 |
2018 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
High miR-376c-3p expression correlated with poor prognostic features, such as large tumor size and venous infiltration.
|
30519319 |
2018 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Overall, miR-21 and miR-376c expression was higher in tumour compared to healthy tissue samples.
|
29348831 |
2017 |