|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
We investigated the key roles and possible regulatory mechanism of miR-370 in regulating HCC metastasis with functional assays, such as transwell assay.
|
30799589 |
2019 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Thus, hsa_circ_0061140 appeared to function as a competing endogenous RNA of miR-370 that promoted cell growth and metastasis in ovarian cancer through regulation of the miR-370/FOXM1 pathway mediating EMT.
|
30236833 |
2018 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Our previous study indicated that miR-370 was able to target forkhead box protein M1 (FOXM1) to inhibit cell growth and metastasis in human osteosarcoma cells.
|
28539830 |
2017 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Our study indicates that miR-370 may bind to the 3'UTR of EGFR to inhibit EGFR expression and the growth, angiogenesis and metastasis of non-small cell lung cancer by down-regulating the ERK1/2 and AKT signaling.
|
29152147 |
2017 |
|
Neoplasm Metastasis
|
0.390 |
AlteredExpression
|
phenotype |
BEFREE |
Our results showed that low miR-370 level significantly correlated with tumor node metastasis stage (p=0.013) and vein invasion (p=0.0082).
|
28925487 |
2017 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
The goal of this study was to identify whether miR‑370 could inhibit the growth, migration, invasion, proliferation and metastasis of gastric cancer through targeting PTEN.
|
27499479 |
2016 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, miR-370 inhibited cell growth and metastasis in osteosarcoma cells by down-regulation of FOXM1.
|
26617733 |
2015 |
|
Neoplasm Metastasis
|
0.390 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of miR-370 inhibited growth and metastasis of HCC cells in vivo.
|
23728999 |
2013 |
|
Neoplasm Metastasis
|
0.390 |
AlteredExpression
|
phenotype |
BEFREE |
Higher expression of miR-370 in GC tissues was associated with more advanced nodal metastasis and a higher clinical stage compared with controls.
|
21666718 |
2012 |
|
Malignant neoplasm of lung
|
0.310 |
Biomarker
|
disease |
BEFREE |
However, the role and molecular mechanisms of miR-370 in regulating the growth and metastasis of lung cancer have not been clarified.
|
29152147 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, the CXCL12/miR-370-3p/HMGA2 signaling pathway is involved in tumor growth and invasiveness of NFPAs.
|
30853598 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results suggest that GRM4 might be a tumor suppressor gene in breast cancer under the direct regulation of miR-328-3p and miR-370-3p.
|
31492116 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Manipulation of WNK2 expression affects miR-370-mediated cell proliferation and tumor growth.
|
31009242 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Later, it was further verified by in vivo experiment that overexpression of miR-370 inhibited tumor growth.
|
31530937 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Besides, low miR-370 and high PIN1 expression significantly correlated with tumor diameter, poor differentiation, tumor invasion and lymph node metastasis in patients diagnosed with ESCC.
|
29605603 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The overexpression of miR-370 in IFN-α-treated LH86 and Huh7 cells increased apoptosis and reduced the volume of LH86- and Huh7-derived xenograft tumors in mice treated with IFN-α compared with the control tumors.
|
29758929 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, overexpression of miR-370 impairs xenograft tumor growth in nude mice.
|
29434862 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, miR-370 inhibited the proliferation of human glioma cells by regulating the levels of β-catenin and the activation of FOXO3a, suggesting that miR-370 was a tumor suppressor in the progression of human astrocytoma and glioblastoma cells.
|
29399110 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Taken together, our study reveals that TRAIL-R1 through regulation of miR-370 can decrease the sensitivity of PDAC cells to TGFβ and therefore represents a potential tumour suppressor in late-stage PDAC.
|
30366420 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our results showed that low miR-370 level significantly correlated with tumor node metastasis stage (p=0.013) and vein invasion (p=0.0082).
|
28925487 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The miR-370 acted as a tumor suppressor in HCC.
|
28387905 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Accumulating evidence has shown that miR-370 play an important role in the development and progression of tumor.
|
28364600 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MicroRNA-370 (miR-370) has been observed to act as a tumor suppressor through the targeting of different proteins in a variety of tumors.
|
28539830 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, miR-370 over-expression significantly reduced the levels of EGFR and CD31 expression and inhibited the growth and lung metastasis of xenograft NSCLC tumors in mice.
|
29152147 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Several reports have indicated that miR-370 acts as a tumor suppressor in varieties of tumors.
|
26617733 |
2015 |