Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The patient had intellectual disability and presented with a prostatic adenocarcinoma with an incidentally identified synchronous sigmoid adenocarcinoma that exhibited deficient MMR with an absence of MSH2 and MSH6 protein expression.Family history was unrevealing.
|
28555354 |
2018 |
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The 6 MMRD small bowel adenocarcinomas had the following expression pattern: 3 with concurrent loss of MSH2 and MSH6, 1 with isolated loss of MSH6, and 2 with concurrent loss of MLH1 and PMS2 in patients with a family history suggestive of genetic cancer susceptibility.
|
27258561 |
2017 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall, 8% (7/91) of adenocarcinomas with primary Gleason pattern 5 (Gleason score 9-10) had MSH2 loss compared with 0.4% (5/1,042) of tumors with any other scores (<i>P</i> < 0.05).
|
28790115 |
2017 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
MSH2 was reduced in 23.4% of NSCLC patients and was significantly associated with adenocarcinoma (P=0.024).
|
24185125 |
2014 |
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This retrospective study included 40 squamous cell carcinomas and 40 adenocarcinomas in various surgical TNM stages to define methylation profile and possible silencing of DNA repair genes - MLH1 and MSH2 - using Methylation-Specific PCR and protein expression by immunohistochemistry in tumoural tissue, preneoplastic lesions and respiratory epithelium with normal histological features.
|
24360395 |
2014 |
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
hMLH1 and hMSH2 mRNA expression was previously evaluated by qPCR for 29 NSCLC patients (13 with squamous cell carcinoma [SQC] and 16 with adenocarcinoma [ADC]) and MMR mRNA levels were converted into clinically distinct phenotypic entities.
|
22865300 |
2013 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The incidence of poorly differentiated adenocarcinoma was 70.6% in HNPCC group among high frequency microsatellite instability (MSI-H), which was higher than the other two groups, which had 50% and 50% respectively.
|
16937450 |
2006 |
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The effect of the hMSH2 haplotypes on the risk of adenocarcinoma was statistically significant in the never smokers and younger individuals (adjusted OR, 0.45; 95% CI, 0.27-0.75; P = 0.002 and P(c) = 0.004; and adjusted OR, 0.44; 95% CI, 0.23-0.85; P = 0.014 and P(c) = 0.028, respectively) but not in the ever-smokers and older individuals.
|
16614121 |
2006 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
We therefore assessed the expression of the MMR proteins MLH1 and MSH2 in a series of 59 Barrett adenocarcinomas and found a loss of MMR protein immunostaining in 2/59 (3%) tumors; one tumor showed a loss of MSH2 expression, the other tumor showed a loss of MLH1, and both tumors displayed an MSI-high phenotype.
|
15676154 |
2005 |
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Quantitative analysis of BRCA1, BRCA2 and Hmsh2 mRNA expression in colorectal Lieberkühnien adenocarcinomas and matched normal mucosa: relationship with cellular proliferation.
|
16158938 |
2005 |
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Sporadic colorectal cancers with defective mismatch repair display a number of specific morphological characteristics: relationship between the expression of hMLH1 and hMSH2 proteins and clinicopathological features of 273 adenocarcinomas.
|
12823711 |
2003 |
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The authors have assessed the frequency of MSI and analyzed the immunohistochemical expression of MLH1 and MSH2 in a population-based series of 89 adenocarcinomas of the small intestine.
|
12627520 |
2003 |
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, we evaluated by immunohistochemistry MLH1 and MSH2 protein expression in 132 MSI-H, 23 MSI-L (low-frequency MSI), and 150 microsatellite stable (MSS) colorectal adenocarcinomas.
|
12118112 |
2002 |
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Hereditary and somatic DNA mismatch repair gene mutations in sporadic endometrial carcinoma.
|
11474654 |
2001 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Compared with MLH1- and MSH2-positive cases, MLH1- or MSH2-deficient colorectal adenocarcinomas were significantly associated on multivariate analysis with a younger age (38 vs. 43 years, P;0.0224), a larger tumour size (60 +/- 6 vs. 46 +/- 2 mm, P=0.0291), an expanding margin (85% vs. 51%, P=0.0159), a higher number of tumour-infiltrating lymphocytes assessed by CD3 immunostaining (202 +/- 48 vs. 33 +/- 4 CD3+ lymphocytes/10 high-power fields, P=0.0039), and a grade 2 Crohn's like lymphoid reaction (70% vs. 9%, P=0.0037).
|
11532035 |
2001 |
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Microsatellite instability and hMLH1/hMSH2 expression in Barrett esophagus-associated adenocarcinoma.
|
11301392 |
2001 |
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We analyzed 100 sporadic and 3 hereditary pancreatic ductal adenocarcinomas for MSI, and high-frequency MSI (MSI-H) and low-frequency MSI (MSI-L) tumors were further analyzed for frameshift mutations of possible target genes and for promoter methylation and mutation of DNA MMR genes, including hMLH1, hMSH2, hMSH3, and hMSH6 genes.
|
11306499 |
2001 |
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MSI and general loss of MSH2 protein expression could be seen in the colorectal tumor but not in the adrenocortical adenocarcinoma.
|
11150379 |
2000 |