Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Although not statistically significant, these results support further research into (i) whether supplemental vitamin D<sub>3</sub> , alone or in combination with calcium, may increase DNA mismatch repair relative to proliferation, increase TGFβ<sub>1</sub> expression, and decrease autocrine/paracrine growth promotion relative to growth inhibition in the colorectal epithelium, all hypothesized to reduce risk for colorectal carcinogenesis; and (ii) the expression of MSH2 relative to mib-1, TGFβ<sub>1</sub> alone, and TGFα relative to TGFβ<sub>1</sub> in the normal-appearing rectal mucosa as potential modifiable, pre-neoplastic markers of risk for colorectal neoplasms.
|
30499618 |
2019 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
mutS homolog 2 (MSH2) deficiency may be involved in the development of microsatellite instability found in certain sporadic colorectal tumors.
|
29715107 |
2018 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
This indicates that hemi- and homozygous hypermethylation of the MSH2 promoter and hence complete silencing of MSH2 expression was responsible for the mismatch repair deficiency in both colorectal tumors.
|
23801599 |
2013 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Analysis of colorectal tumors from probands included a microsatellite instability study and immunohistochemical evaluation for MLH1 and MSH2.
|
20305446 |
2010 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Three new nonsense mutations of MLH1 and MSH2 genes in Korean families with hereditary nonpolyposis colorectal cancer.
|
19100506 |
2009 |
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Reduced mRNA expression in paraffin-embedded tissue identifies MLH1- and MSH2-deficient colorectal tumours and potential mutation carriers.
|
18581137 |
2008 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects.
|
18299982 |
2008 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer.
|
18949393 |
2008 |
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
MSH2 missense mutations and HNPCC syndrome: pathogenicity assessment in a human expression system.
|
18781619 |
2008 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer.
|
18949393 |
2008 |
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Germline MLH1 and MSH2 mutational spectrum including frequent large genomic aberrations in Hungarian hereditary non-polyposis colorectal cancer families: implications for genetic testing.
|
17569143 |
2007 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Novel hMSH2, hMSH6 and hMLH1 gene mutations and microsatellite instability in sporadic colorectal cancer.
|
16902769 |
2007 |
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
High proportion of large genomic rearrangements in hMSH2 in hereditary nonpolyposis colorectal cancer (HNPCC) families of the Basque Country.
|
17582678 |
2007 |
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
A novel MSH2 mutation in a Chinese family with hereditary non-polyposis colorectal cancer.
|
17333219 |
2007 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: Influence of smoking.
|
16874859 |
2006 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Loss of protein expression of hMLH1 and hMSH2 with double primary carcinomas of the stomach and colorectum.
|
16786121 |
2006 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Immunohistochemistry detects mismatch repair gene defects in colorectal cancer.
|
16684085 |
2006 |
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Clinical and molecular characteristics of hereditary non-polyposis colorectal cancer families in Southeast Asia.
|
15996210 |
2005 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Overall, the prevalence of MSI-H colorectal tumor was 2-3-fold higher, while the defect in the percentage expression of mismatch repair (MMR) genes (hMLH1 and hMSH2) was similar in AA patients compared to the U.S. Caucasian population.
|
15856472 |
2005 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
The role of MLH1, MSH2 and MSH6 in the development of multiple colorectal cancers.
|
16106253 |
2005 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Correlation between hMLH1/hMSH2 and p53 protein expression in sporadic colorectal cancer.
|
15816455 |
2005 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
The 5' region of the MSH2 gene involved in hereditary non-polyposis colorectal cancer contains a high density of recombinogenic sequences.
|
16086322 |
2005 |
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The authors evaluated the frequency of the carrier status of three ancestral colorectal neoplasm-associated mutations (APC:I1307K, BLM(Ash), and MSH2*1906G>C) found in the Jewish population among a case series with documented colorectal neoplasms.
|
15959913 |
2005 |
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Oncogenic pathway of sporadic colorectal cancer with novel germline missense mutations in the hMSH2 gene.
|
12792735 |
2004 |
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We demonstrate in one family that a hMLH3 mutation segregated with disease together with a missense mutation in hMSH2, which makes us hypothesize that these mutations work together in an additive manner and result in an elevated risk of colorectal tumors in the family.
|
12702580 |
2003 |