|
Inflammatory Bowel Diseases
|
0.190 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
|
Inflammatory Bowel Diseases
|
0.190 |
GeneticVariation
|
group |
BEFREE |
Importantly, we discovered that serum protein levels of MST1 (Macrophage Stimulating 1) were regulated by SNP rs3197999 (p = 5.96E-10, FDR<5%), an accepted GWAS locus for IBD.
|
28129359 |
2017 |
|
Inflammatory Bowel Diseases
|
0.190 |
GeneticVariation
|
group |
BEFREE |
Three loci (NOD2, MHC, and MST1 3p21) were associated with subphenotypes of inflammatory bowel disease, mainly disease location (essentially fixed over time; median follow-up of 10·5 years).
|
26490195 |
2016 |
|
Inflammatory Bowel Diseases
|
0.190 |
AlteredExpression
|
group |
BEFREE |
We included 1721 patients with CD of which 524 (30.4%) were pCD+ and 1197 were pPCD. pCD was associated with distal colonic disease (Odds ratio 5.54 [3.23-9.52], P < 0.001), stricturing disease behavior (1.44 [1.14-1.81], P = 0.002) and family history of inflammatory bowel disease (4.98 [3.30-7.46], P < 0.001). pCD was associated with higher anti-sacharomyces cerevisae antibodies IgA (P < 0.001) and OmpC (P = 0.008) antibody levels. pCD was associated with known inflammatory bowel disease loci, including KIF3B, CRTC3, TRAF3IP2, JAZF1, NRIP1, MST1, FUT2, and PTGER (all P < 0.05).
|
26937622 |
2016 |
|
Inflammatory Bowel Diseases
|
0.190 |
Biomarker
|
group |
BEFREE |
We propose that GPx-1 is a better candidate than MST1 for the pathophysiologic link between IBD locus 12 and IBD.
|
26355565 |
2015 |
|
Inflammatory Bowel Diseases
|
0.190 |
GeneticVariation
|
group |
BEFREE |
We investigated the consequences of this polymorphism for MSP-RON pathway activity and IBD pathogenesis.
|
24409221 |
2013 |
|
Inflammatory Bowel Diseases
|
0.190 |
GeneticVariation
|
group |
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
Inflammatory Bowel Diseases
|
0.190 |
GeneticVariation
|
group |
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
Inflammatory Bowel Diseases
|
0.190 |
GeneticVariation
|
group |
BEFREE |
Therefore, the gain of function observed with rs3197999 in MST1 might provide a cellular mechanism for the consistent association of this polymorphism with an increased risk for IBD and PSC.
|
22237417 |
2012 |
|
Inflammatory Bowel Diseases
|
0.190 |
Biomarker
|
group |
BEFREE |
We confirmed the association of BSN and MST1 with IBD susceptibility, either in the adult or the early-onset cohorts.
|
20024904 |
2010 |
|
Inflammatory Bowel Diseases
|
0.190 |
GeneticVariation
|
group |
BEFREE |
Effect of BSN-MST1 locus on inflammatory bowel disease and multiple sclerosis susceptibility.
|
19657358 |
2009 |
|
Inflammatory Bowel Diseases
|
0.190 |
GeneticVariation
|
group |
BEFREE |
R689C is predicted to interfere with MSP binding to its receptor, suggesting a role for this gene in the pathogenesis of IBD.
|
19079170 |
2008 |