Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In short, COX-2 or 5-LOX deletion and its inhibitors enhanced activity of PTEN and suppressed cell and adenoma progression through PI3K/AKT pathway in colorectal cancer.
|
29339153 |
2019 |
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To elucidate the involved mechanisms, two colon-relevant metabolites of the polyphenolic and fiber PMD components, urolithin-A (u-A) and sodium butyrate (SB), are tested alone or in combination in vitro (colon cancer cells), and ex vivo in adenoma (AD) and normal mucosa (NM) from Pirc rats. u-A 25 μm plus SB 2.5 mm (USB) causes a significant reduction in COX-2 protein expression compared to untreated controls (about -70% in cancer cell cultures, AD, and NM), and a strong increase in C-CASP-3 expression in cells (about ten times), in AD and NM (+74 and +69%).
|
28948694 |
2018 |
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
COX-2 inhibitors seem to be more effective in preventing recurrence of adenomas; however, there was a trend of an increased risk of recurrence of adenomas observed after discontinuing regular use.
|
29137605 |
2017 |
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Paracrine macrophage Cox-2 activity drives growth and progression of Apc <sup>Min/+</sup> mouse colonic adenomas, linked to increased epithelial cell β-catenin dysregulation.
|
28729694 |
2017 |
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Several genes including Tiam1, Gastrin, CD44, uPA, Igfbp4, VEGF and Cox-2 that are known to be transcriptionally regulated by activation of the Wnt signaling pathway were found to be expressed at higher levels in the large intestinal adenomas from K-rasVal12/Cre/ApcMin/+ mice compared with those from controls, although other Wnt signaling pathway target genes remained unchanged.
|
21573497 |
2011 |
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
COX-2 expression could be assessed in 219 adenomas from 136
|
20427397 |
2010 |
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The data from our pilot study suggest that allelic variants of the COX-2 gene significantly influence the risk of adenoma development in the African American population.
|
19031967 |
2009 |
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, pharmacologic inhibition or gene silencing of 11betaHSD2 inhibited COX-2-mediated PGE2 production in tumors and prevented adenoma formation, tumor growth, and metastasis in mice.
|
19307727 |
2009 |
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, we show that the adenoma prevention activity of the COX-2 inhibitor celecoxib requires the concomitant presence of the 15-hydroxyprostaglandin dehydrogenase (15-PGDH) tumor suppressor gene, and that loss of 15-PGDH expression imparts resistance to celecoxib's anti-tumor effects.
|
19470469 |
2009 |
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Third, using the Apc Min/+ mice model, we demonstrated that inhibition of the CD44v6 expression reduces the signaling through a hyaluronan/CD44v6-pErbB2-Cox-2 interaction pathway and reduced adenoma number and growth.
|
19246453 |
2009 |
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In a community-, colonoscopy-based case-control study with 162 incident, sporadic colorectal adenoma cases and 211 controls, we investigated associations of two promoter polymorphisms (-842 A > G in COX1 and -765 G > C in COX2) and two polymorphisms in the 3'-UTR of COX2 (8473 T > C and 9850 A > G) with risk of adenomas.
|
19205707 |
2009 |
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HuR and COX-2 protein expression were studied by immunohistochemistry of normal colon mucosa (N=20), adenomas (N=112), carcinomas (N=9) from patients with FAP, and 141 sporadic colorectal adenocarcinomas (Dukes B and C).
|
18094611 |
2008 |
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Traditional serrated adenomas and non-serrated adenomas showed similar frequencies of COX-2 overexpression.
|
18230181 |
2008 |
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
We investigated interactions between dietary fish intake and polymorphisms in cyclooxygenase (COX)-1, COX-2, ALOX5 and PGIS in a case-control study of adenomas (N = 522), hyperplastic polyps (N = 194) and polyp-free controls (N = 626).
|
17277229 |
2007 |
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
An increase in adenoma risk was observed for the TC genotype of SNP c.2242T-->C in COX-2 (OR 1.47, 95% CI 1.07-2.00) compared with the TT genotype.
|
15550453 |
2005 |
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
COX-2 expression did not differ significantly in tubular compared with tubulovillous adenomas, although there appeared to be a trend toward higher COX-2 expression in tubulovillous adenomas with increasing villous content.
|
12873979 |
2003 |
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
In the same patient, COX-2 was negative in the hyperplasia region but positive in adenoma and adenocarcinoma regions, showing results reflecting the progression of the disease.
|
11920515 |
2002 |
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Selective COX-2 inhibitors reduce adenoma formation and cancer progression in rodent models of colorectal cancer.
|
11687954 |
2002 |
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, the increase of COX-2-positive cells in the lesion was observed more frequently in tubulovillous (63.6%) than in tubular (36.4%) adenoma.
|
11129221 |
2000 |
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
There were no correlations between Cox-2 protein expression and proliferative or apoptotic index in either adenomas or carcinomas (all p > 0.25).
|
10398082 |
1999 |
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In six pairs of colorectal adenomas and normal mucosa, three showed up-regulation of COX-2 in the adenoma compared with the normal mucosa.
|
7926468 |
1994 |