Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The modulation of COX mediated pathways in UC-associated inflammation was observed by protein expressions of various pro-inflammatory cytokines such as TNF-α and enzymes of PG synthesis such as COX-2, PGES, TXAS, and anti-inflammatory PGDS.
|
30489199 |
2019 |
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
COX-2-PGE<sub>2</sub> Signaling Impairs Intestinal Epithelial Regeneration and Associates with TNF Inhibitor Responsiveness in Ulcerative Colitis.
|
30190207 |
2018 |
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Colonic epithelial mTORC1 promotes ulcerative colitis through COX-2-mediated Th17 responses.
|
30082707 |
2018 |
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To carry out a systematic review and meta-analysis of previous studies examining the association between acetaminophen and NSAIDs including cyclooxygenase (COX-2) inhibitors use, and risk of Crohn's disease (CD) and ulcerative colitis (UC) exacerbation.
|
29620794 |
2018 |
Ulcerative Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, AGNE suppressed the increased expression of COX-2 and HIF-1α and the increased production of PGE<sub>2</sub> in colon tissue were observed in mice with DSS-induced UC.
|
29080614 |
2017 |
Ulcerative Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, treatment with D‑limonene significantly increased antioxidant, inducible nitric oxide synthase (iNOS) and cyclooxygenase‑2 (COX‑2) protein expression levels in UC rats.
|
28260017 |
2017 |
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study for the first time demonstrated differential expression of the PGE2-related enzymes COX-2 and 15-PGDH in colonic mucosa from UC, CD, and acute DD.
|
25666316 |
2015 |
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
COX-2 immunostaining was positive (total score >=3) in 72.5% of all the UC cases studied.
|
23529322 |
2013 |
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine the effect of non-selective cyclooxygenase (COX) inhibitors, selective COX-2 inhibitors and nitric oxide (NO)-releasing aspirin in the healing of ulcerative colitis.
|
22039321 |
2011 |
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
COX-2 A-1195G polymorphism was associated with the risk of UC, especially among never-smokers, suggesting that low activity of COX-2 may predispose to UC.
|
20803508 |
2011 |
Ulcerative Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present study was: 1) to examine the expression of ghrelin and TNF-alpha mRNA in the inflamed colonic mucosa of patients with ulcerative colitis (UC), 2) to analyze the effect of treatment with exogenous ghrelin on the healing of trinitrobenze sulphonic acid (TNBS)-induced colitis in rats, and 3) to assess the effects of ghrelin treatment on mRNA expression for iNOS and protein expression for COX-2 and PPARalpha in intact colonic mucosa and in that with TNBS-induced colitis.
|
19617644 |
2009 |
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
An effect of the COX-2 polymorphism on both CD and UC was shown which is compatible with the presence of a recessive allele in linkage equilibrium with the SNP marker in the COX-2 gene.
|
18819034 |
2009 |
Ulcerative Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
COX-2 overexpression occurs early in UC-associated neoplasia, and the increase cannot be explained by inflammatory activity alone.
|
10980113 |
2000 |
Ulcerative Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
COX-2 expression was absent from normal colon, whereas in Crohn's colitis and ulcerative colitis, COX-2 was observed in apical epithelial cells and in lamina propria mononuclear cells.
|
9679035 |
1998 |