CYTB, cytochrome b, 4519

N. diseases: 166; N. variants: 83
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024530
Disease: Malaria
Malaria
0.100 Biomarker disease BEFREE A genus-specific conventional cytochrome b (cytb) PCR has shown high sensitivity in field studies, detecting 70% submicroscopic malaria. 31276473 2019
CUI: C0024530
Disease: Malaria
Malaria
0.100 Biomarker disease BEFREE Cytochrome b-nested PCR was used to detect malaria parasites from blood samples collected on a filter paper on day 3. 30860013 2019
CUI: C0024530
Disease: Malaria
Malaria
0.100 GeneticVariation disease BEFREE This systematic review assesses the clinical efficacy of atovaquone/proguanil treatment of uncomplicated malaria and examines the extent to which codon 268 mutation in cytochrome b influences treatment failure and recrudescence based on published information. 29237012 2018
CUI: C0024530
Disease: Malaria
Malaria
0.100 Biomarker disease BEFREE The phylogeny based on partial cytochrome b (cyt b) sequences suggests that this parasite is most closely related to Plasmodium tejerai (cyt b lineage pSPMAG01), a common malaria parasite of American birds. 28931453 2017
CUI: C0024530
Disease: Malaria
Malaria
0.100 Biomarker disease BEFREE Using dried blood spot samples from patients with suspected malaria at 37 health facilities from 2012 to 2014 in the low-endemicity country of Swaziland, we investigated the diagnostic accuracy of histidine-rich protein 2-based RDTs using qualitative polymerase chain reaction (PCR) (nested PCR targeting the cytochrome b gene) and quantitative PCR as reference standards. 28369268 2017
CUI: C0024530
Disease: Malaria
Malaria
0.100 Biomarker disease BEFREE Based on HRM analysis of vertebrate cytochrome b, 16S rRNA and COI PCR products, humans (72.36%) were the prominent blood-meal hosts of malaria vectors, but 20.91% of blood-meals were from non-human vertebrate hosts. 28886724 2017
CUI: C0024530
Disease: Malaria
Malaria
0.100 Biomarker disease BEFREE SYBR Green real-time PCR-RFLP assay targeting the plasmodium cytochrome B gene--a highly sensitive molecular tool for malaria parasite detection and species determination. 25774805 2015
CUI: C0024530
Disease: Malaria
Malaria
0.100 Biomarker disease BEFREE The prevalence of cytbPCR-detectable malaria infection was 2% (12 of 594), including 8 P. falciparum, 3 Plasmodium malariae, and 1 Plasmodium vivax infections. 23249688 2013
CUI: C0024530
Disease: Malaria
Malaria
0.100 Biomarker disease BEFREE A cytochrome b (cytb) gene quantitative PCR (qPCR) assay was developed to diagnose malaria in travelers. 21508150 2011
CUI: C0024530
Disease: Malaria
Malaria
0.100 GeneticVariation disease BEFREE Mutations in the Plasmodium falciparum cytochrome b gene are associated with delayed parasite recrudescence in malaria patients treated with atovaquone-proguanil. 19021900 2008
CUI: C0024530
Disease: Malaria
Malaria
0.100 GeneticVariation disease BEFREE The atovaquone resistance of malaria parasites correlates with mutations in the cytochrome b gene. 16690094 2006
CUI: C0024530
Disease: Malaria
Malaria
0.100 GeneticVariation disease BEFREE The prevalence of codon-268 mutations in the cytb gene of African P. falciparum isolates from Nigeria, Malawi and Senegal, where atovaquone-proguanil has not been introduced for treatment of malaria was assessed. 17020611 2006
CUI: C0024530
Disease: Malaria
Malaria
0.100 Biomarker disease BEFREE Molecular epidemiology of malaria in Cameroon. XVII. Baseline monitoring of atovaquone-resistant Plasmodium falciparum by in vitro drug assays and cytochrome b gene sequence analysis. 14506774 2003