NUDT1, nudix hydrolase 1, 4521

N. diseases: 73; N. variants: 3
Disease: Liver carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.040 Biomarker disease BEFREE The MTH1 inhibitor Karonudib (TH1579) and siRNA effectively introduce toxic oxidized nucleotides into DNA, 8-oxoG, and kill HCC cell lines <i>in vitro</i>. 31489034 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.040 GeneticVariation disease BEFREE Nineteen tagging SNPs in base excision repair genes (including MUTYH, OGG1 and MTH1) were genotyped using iPLEX assays; one significant SNP was found and confirmed in Japanese patients with chronic hepatitis C (CHC) (n = 38 HCC and 55 controls). 30218772 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.040 AlteredExpression disease BEFREE CDT1, MCM7, and NUDT1 were shown to be up-regulated in HCC tissues through quantitative real-time PCR. 29442275 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.040 AlteredExpression disease BEFREE In addition, the mRNA level of MTH1 was upregulated in the liver tissues of HCC rats (<i>P</i> < 0.05 versus control group), which was reversed by HS-1200 treatment in a dose-dependent manner (<i>P</i> < 0.05 versus HCC group).<i>Conclusions</i>. 28261604 2017