|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest associations of the MTHFR gene variant with schizophrenia and depression in the Japanese.
|
9342205 |
1997 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Arinami et al found an increased frequency of homozygosity for the mutated type (T677) of the MTHFR gene in schizophrenia and depression.
|
9774778 |
1998 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Patients with late-onset depression had a higher prevalence of the homozygous or heterozygous forms of the C677T mutation of the methylenetetrahydrofolate reductase enzyme (MTHFR)(74% v. 48% in patients with early-onset disorders, P < 0.05).
|
11722155 |
2001 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Forty-seven persons with depression (mean age=51.8 years, SD=12.4) and 20 healthy volunteers (mean age=56.1 years, SD=9.8) underwent clinical assessments, a neuropsychological test of psychomotor speed (part A of the Trail Making Test), high-resolution magnetic resonance imaging scans, and genotyping for the apolipoprotein E epsilon4 allele and a mutation of the methylenetetrahydrofolate reductase enzyme.
|
12450963 |
2002 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Overall, hyperhomocysteinemia (plasma total homocysteine level > or =15.0 micro mol/L [> or =2.02 mg/dL]) (odds ratio, 1.90; 95% confidence interval, 1.11-3.25) and T/T methylenetetrahydrofolate reductase genotype (odds ratio, 1.69; 95% confidence interval, 1.09-2.62), but not low plasma folate or vitamin B12 levels, were significantly related to depression without comorbid anxiety disorder.
|
12796225 |
2003 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
CTD_human |
Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review.
|
17074966 |
2007 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Odds ratio (OR) for women with depression and MTHFR TT genotype was 3.478 (95% CI=1.377-8.783), P=0.0096 and OR of the TT and CT genotypes was 2.345 (95% CI=1.258-4.373), P=0.0086.
|
18801628 |
2008 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The triangular association between the MTHFR genotype, tHcy, and depression implies that higher concentrations of tHcy increase the risk of depression and that lowering tHcy by 0.19 mg/L could reduce the odds of depression by about 20%.
|
18981340 |
2008 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
No association with the 5,10-methylenetetrahydrofolate reductase gene and major depressive disorder: results of the depression case control (DeCC) study and a meta-analysis.
|
18165972 |
2008 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
MTHFR TT genotype was more prevalent in AD patients with milder alcohol dependence (Babor type A) and with Lesch type 3, associated with depression.
|
19650814 |
2009 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
For the MTHFR genotypes, the association between the number of somatic disorders and depression was significant in T/T homozygotes (chi2 = 4.97, p = .026) but not in C/T heterozygotes (chi2 = 1.24, p = .265) or C/C homozygotes (chi2 = 1.04, p = .307).
|
19251870 |
2009 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association analysis of the COMT/MTHFR genes and geriatric depression: an MRI study of the putamen.
|
19235787 |
2009 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Stepwise multiple regression was used to determine the best statistical model to predict depression; C677T-MTHFR (p=0.0103) was found to be positively associated with depression, while the thiol dipeptide Cys-Gly was negatively associated (p=0.0403).
|
21125200 |
2010 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We found that genotype Met/Met of the Val66Met polymorphism of the brain-derived neurotrophic factor gene was positively associated with depressive disorder (P < 0.05), but we were not able to find any significant associations of both the depressive disorder and metabolic syndrome with the remaining polymorphisms studied (methylenetetrahydrofolate reductase 677CT, methylenetet rahydrofolate reductase 1298AC, endothelial nitric oxide synthase Glu298Asp, and tyrosine hydroxylase).
|
20163778 |
2010 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
MTHFR C677T is associated with MA in individuals selected for depression study.
|
21635773 |
2011 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that MTHFR C677T polymorphism may be linked more to loneliness than depression in the cognitively normal elderly males, and may be implicated in the pathophysiology of late-life depression in relation to MTHFR genes.
|
22668858 |
2012 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, we did find evidence to suggest that folic acid supplements during pregnancy protected against depression 21 months postpartum, and that this effect was more pronounced in those with the MTHFR C677T TT genotype (change in depression score from 8 months to 21 months postpartum among TT individuals was 0.66 (95% CI=0.31-1.01) among those not taking supplements, compared with -1.02 (95% CI=-2.22-0.18) among those taking supplements at 18 weeks pregnancy, P(difference)=0.01).
|
21772318 |
2012 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No statistically significant difference was observed when global DNA methylation were stratified according to C677T MTHFR genotypes (p = 0.7200), BMI (p = 0.1170), smoking habit (p = 0.4382), physical activity in daily life (p = 0.8492), scored cognitive function (p = 0.7229) or depression state (p = 0.8301).
|
23285094 |
2012 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The current study did not find evidence of an association between the MTHFR C677T TT genotype and impaired cognition or depression in a population with adequate folate status and a high prevalence of cognitive impairment and depression.
|
22739363 |
2012 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Interaction between the MTHFR C677T polymorphism and traumatic childhood events predicts depression.
|
23900311 |
2013 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A common C677T polymorphism in MTHFR has been associated with an increased risk for the development of cardiovascular disease, Alzheimer's disease, and depression in adults, and of neural tube defects in the fetus.
|
23116396 |
2013 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
A common C677T polymorphism in MTHFR has been associated with an increased risk for the development of cardiovascular disease, Alzheimer's disease, and depression in adults, and of neural tube defects in the fetus.
|
23116396 |
2013 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Homocysteine and MTHFR C677T polymorphism in children and adolescents with psychotic and mood disorders.
|
23586533 |
2014 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Significance of dietary folate intake, homocysteine levels and MTHFR 677 C>T genotyping in South African patients diagnosed with depression: test development for clinical application.
|
24532086 |
2014 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this study, we aimed to examine whether the COMT-MTHFR genotype interacted with cognitive function in late-onset depression (LOD) patients and COMT Val/Val homozygous individuals who also carried the MTHFR T allele and had poor neuropsychological test performance.
|
24373005 |
2014 |