|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphism is associated with antipsychotic-induced weight gain in first-episode schizophrenia.
|
24229535 |
2014 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
MTHFR C677T increased schizophrenia risk in a dose-dependent manner per MTHFR T allele (P = 0.005) consequent upon CA exposure.
|
28556887 |
2017 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
MTHFR A1298C polymorphism was found to be a risk factor for schizophrenia and might have played a significant role in the pathogenesis of schizophrenia.
|
28862175 |
2017 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met and methylenetetrahydrofolate reductase (MTHFR) C677T has been shown to differentially affect cognition in patients with schizophrenia and healthy controls; the effect of COMT Val158Met × MTHFR interaction on resilience to stress in patients and controls remains to be examined.
|
22128864 |
2012 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A second polymorphism, methylenetetrahydrofolate reductase (MTHFR) 677C --> T (rs1801133), has been associated with overall schizophrenia risk and executive function impairment in patients, and may influence dopamine signaling through mechanisms upstream of COMT effects.
|
18988738 |
2008 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Among the Scandinavian patients the functional MTHFR SNP rs1801133 (C677T) significantly affected age at onset of schizophrenia in a dose-dependent manner (P = 0.0015), with lower age of onset with increasing numbers of the mutant T-allele.
|
19746410 |
2010 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association study of methylenetetrahydrofolate reductase genetic polymorphism 677C>T with schizophrenia in hospitalized patients in population of European Russia.
|
29202425 |
2018 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
COMT and MTHFR polymorphisms interaction on cognition in schizophrenia: an exploratory study.
|
23353103 |
2013 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
DNA methylation in schizophrenia subjects: gender and MTHFR 677C/T genotype differences.
|
22690662 |
2012 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Elevated Hcy levels and, in line with this finding, homozygosity for the 677C-->T mutation in the MTHFR gene were not associated with an increased risk for schizophrenia.
|
14572619 |
2003 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Elevated homocysteine levels and the MTHFR 677TT genotype are associated with an increased risk for schizophrenia.
|
15806605 |
2005 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Folate supplementation in schizophrenia: a possible role for MTHFR genotype.
|
21334854 |
2011 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase C677T polymorphism, are risk factors for schizophrenia.
|
19939410 |
2010 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
From this work, genetic variation within both the methylenetetrahydrofolate reductase (MTHFR) gene and the catechol-O-methyltransferase (COMT) gene has been associated with an increased risk of metabolic syndrome in schizophrenia patients treated with AAPs.
|
23341251 |
2013 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Further evidence that methylenetetrahydrofolate reductase A1298C polymorphism is a risk factor for schizophrenia.
|
20694488 |
2010 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Gene-wide association study between the methylenetetrahydrofolate reductase gene (MTHFR) and schizophrenia in the Japanese population, with an updated meta-analysis on currently available data.
|
20692813 |
2010 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic analysis of the thermolabile methylenetetrahydrofolate reductase variant in schizophrenia and mood disorders.
|
15564899 |
2004 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Genetic analysis of the thermolabile methylenetetrahydrofolate reductase variant in schizophrenia and mood disorders.
|
15564899 |
2004 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2.
|
22037552 |
2011 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
GRS based on three SNPs (CENPQ, CPS1, and MTHFR) was significantly associated with SCZ.
|
27810229 |
2016 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Homozygous thermolabile methylenetetrahydrofolate reductase in schizophrenia-like psychosis.
|
9451725 |
1997 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, it is unclear whether the polymorphism of MTHFR could be an independent or an add-on risk factor for specific psychiatric symptoms, such as anxiety, depression, positive, or negative symptoms of schizophrenia, or acts as risk factor for specific psychiatric disorders, such as schizophrenia, major depression, autisms, and bipolar disorders.
|
30397195 |
2018 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion the results of the present meta-analysis suggested that the MTHFR C677T polymorphism is a risk factor for schizophrenia.
|
27025471 |
2016 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, both elevated plasma homocysteine levels and variation in the MTHFR 677C-->T gene are related to increased rates of schizophrenia and are risk factors for schizophrenia.
|
19564051 |
2009 |