|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To determine prevalence of methylenetetrahydrofolate reductase (MTHFR) mutations in apparently healthy individuals residing in Mumbai and patients with deep vein thrombosis (DVT) and coronary artery disease (CAD) and to correlate these polymorphisms with homocysteine (Hcy) levels.
|
31571711 |
2020 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the 677th site C/T in MTHFR gene for 101 patients with lower extremities deep venous thrombosis (DVT group) and 120 healthy subjects (control group) were detected by polymerase chain reaction with sequence-specific primers.
|
30303041 |
2019 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Moreover, the MTHFR rs1801133 polymorphism may be implicated in the development of deep vein thrombosis and pulmonary embolism, while the MTHFR rs1801131 polymorphism may contribute to the development of pulmonary embolism.
|
30466296 |
2019 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Thus, the aim of the present study is to determine the prevalence of FVL, MTHFR C677T and MTHFR A1298C gene polymorphisms in patients with DVT in central Iran.
|
29855758 |
2018 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
GpIIIa 1565T/C and homozygous MTHFR 677C/T polymorphisms were higher in DVT patients compared with the control group (OR=6.65, 95% CI=3.09-14.30 and OR=4.08, 95% CI=1.35-12.38, respectively).
|
26261166 |
2015 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
PAI-1 4G/5G and MTHFR C677T polymorphisms increased the accuracy of two prediction scores for the risk of acute lower extremity deep vein thrombosis.
|
24715181 |
2014 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The authors described a unique patient with Klinefelter's syndrome who presented with deep vein thrombosis of the leg and underlying mutations of MTHFR gene, increased factor VIII coagulant activity and an elevated anticardiolipin antibody.
|
23377169 |
2013 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, the frequency of the MTHFR C677T polymorphism was significantly higher in patients with SVT compared with DVT (CT 12 versus 10, and TT 7 versus 1, respectively, P < 0.001).
|
20881312 |
2011 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The presence of homozygous MTHFR A1298C mutation was significantly associated with DVT (P=0.020).
|
21080081 |
2011 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The aim of present study was to investigate the prevalence of factor V Leiden (FVL) c.1691G>A, prothrombin g.20210G>A and methylenetetrahydrofolate reductase (MTHFR) c.677C>T in deep vein thrombosis (DVT) patients and their possible association with DVT in western Iran.
|
20479641 |
2010 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In addition, only MTHFR C677T polymorphism constituted a molecular biomarker of DVT in Chilean population.
|
20707729 |
2010 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Patients with homozygous or combined heterozygous status of MTHFR C677T and A1298C mutation had a higher frequency of DVT after elective THA (odds ratio, 2.86; 95% confidence interval, 1.32-6.35) than those with wild-type.
|
18800213 |
2009 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The frequency of T allele of MTHFR-677 was lower in healthy participants (0.355) than in patients with occlusive artery disease (0.388) and deep venous thrombosis (0.425).
|
18293456 |
2008 |
|
Deep Vein Thrombosis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Acute anuric renal failure with streptokinase therapy in a patient with acute venous thromboembolic disease and the review of renal side effects of streptokinase.
|
19123085 |
2008 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Plasma concentration of tHcy in AC genotype of MTHFR A1298C was increased in patients with OAD and in patients with DVT.
|
18800176 |
2008 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A mutation in the factor V and methylenetetrahydrofolate reductase (MTHFR) gene, the commonest inherited risk factor for venous thrombosis, may contribute to the risk of both arterial and deep-vein thrombosis in patients with nephrotic syndrome.
|
18030499 |
2008 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We studied prothrombotic determinants, namely protein C, protein S, and AT along with factor V Leiden (1691G-->A), prothrombin gene mutation (20210G-->A), CBS 844ins68 mutation, and MTHFR mutation (677C-->T) in consecutive ethnic Omani patients with first episode of a thrombophilic event, namely, deep vein thrombosis (DVT), and/or pulmonary embolism (PE) or thrombosis at an unusual site.
|
16432849 |
2006 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The homozygous 677TT mutation of the MTHFR gene has been linked to deep vein thrombosis and to arterial atherosclerotic events of the coronary, carotid and peripheral arteries.
|
16158041 |
2005 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To determine the incidence of deep venous thrombosis (DVT) recurrence in young people, and its association with some genetic polymorphisms (FV G1691A, FII G20210A, MTHFR C677T, PAI-1 4G/5G).
|
16061406 |
2005 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This indicates that FV-Leiden and PRT G20210A, more than MTHFR C677T, are important risk factors for DVT, and that the presence of more than one prothrombotic SNPs was associated with a significant risk of DVT.
|
16082606 |
2005 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, MTHFR TT677 does not appear to be an important risk factor for DVT, EPCR 403ins23 seems to be very rare, its role in the development of DVT unclear.
|
12413583 |
2002 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, we found that the VV genotype of the MTHFR gene is a risk factor for DVT only when combined with the predisposition of thrombophilia.
|
10706928 |
2000 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
MTHFR gene C677T mutation does not increase risk of DVT in BD either alone or combined with FV Leiden mutation.
|
11128675 |
2000 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We investigated the prevalence of a genetic variation in the 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene (C677T) using polymerase chain reaction techniques in a sample of 500 general Thai population and among 40 unselected Thai patients with an objectively confirmed history of deep vein thrombosis (DVT).
|
11014892 |
2000 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These data do not support a critical role of MTHFR 1298 A --> C in the predisposition to DVT.
|
10233437 |
1999 |