|
Cervical Intraepithelial Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between methylenetetrahydrofolate reductase C677T polymorphism, HPV infection and cervical intraepithelial neoplasia in Brazilian women.
|
31170928 |
2019 |
|
Cervical Intraepithelial Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Studies in populations unexposed to folic acid (FA) fortification have demonstrated that MTHFR C677T polymorphism is associated with increased risk of higher grades of cervical intraepithelial neoplasia (CIN 2+).
|
25302494 |
2014 |
|
Cervical Intraepithelial Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study suggests that the A1298C-MTHFR polymorphism contributes to the genetic risk for both CIN and ICC, whereas the Arg72Pro-p53 polymorphism only contributes to the risk for CIN.
|
24474455 |
2014 |
|
Cervical Intraepithelial Neoplasia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Numerous case-control studies on the association between polymorphisms of key genes involved in methionine remethylation [methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS)] and the susceptibility of cervical intraepithelial neoplasia (CIN) and cervical cancer have provided inconclusive results.
|
23864153 |
2013 |
|
Cervical Intraepithelial Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to cervical cancer and cervical intraepithelial neoplasia: a meta-analysis.
|
23029458 |
2012 |
|
Cervical Intraepithelial Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Serum folate concentration is inversely associated with the risk of cervical cancer, and the MTHFR variant genotype may increase CIN and cervical cancer risk in women with low folate or vitamin B12 status.
|
21052817 |
2011 |
|
Cervical Intraepithelial Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The effects of polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women.
|
19760026 |
2010 |
|
Cervical Intraepithelial Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A decreased risk for CIN of individuals homozygous for the MTHFR T allele was shown.
|
20130515 |
2010 |
|
Cervical Intraepithelial Neoplasia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
MTHFR polymorphism was not associated with CIN 2 or 3 in women with high riboflavin status (OR 0.51, 95% CI 0.22-1.19, P = 0.119), nor were any of the associations influenced by folate levels.
|
17303386 |
2007 |
|
Cervical Intraepithelial Neoplasia
|
0.400 |
Biomarker
|
disease |
CTD_human |
MTHFR polymorphism was not associated with CIN 2 or 3 in women with high riboflavin status (OR 0.51, 95% CI 0.22-1.19, P = 0.119), nor were any of the associations influenced by folate levels.
|
17303386 |
2007 |
|
Cervical Intraepithelial Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Protective association of MTHFR polymorphism on cervical intraepithelial neoplasia is modified by riboflavin status.
|
17303386 |
2007 |
|
Cervical Intraepithelial Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene are thought to be associated with a varying risk of cervical dysplasia.
|
16297972 |
2006 |
|
Cervical Intraepithelial Neoplasia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Four polymorphisms (Tp53, IL-10, CYP2D6 and the MTHFR) exhibited an increased CIN and cervical cancer risk.
|
15703836 |
2005 |
|
Cervical Intraepithelial Neoplasia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conducted a study to examine associations between polymorphisms in folate pathway coenzymes (methylenetetrahydrofolate reductase [MTHFR] and methionine synthase [MS]) and cervical intraepithelial neoplasia (CIN) 2 or 3 in a population exposed to folic acid by the food fortification program in the United States.
|
15514969 |
2005 |
|
Cervical Intraepithelial Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we have examined a large study population to determine whether the C677T polymorphism at the MTHFR locus affects susceptibility for cervical cancer or its precursor, cervical intraepithelial neoplasia (CIN).
|
15635481 |
2005 |
|
Cervical Intraepithelial Neoplasia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Compared with MTHFR C/C, the odds ratio (95% confidence interval) for MTHFR T/T was 1.4 (0.9-2.3) for invasive cervical cancer and 1.3 (0.8-2.3) for cervical intraepithelial neoplasia (CIN) II or III.
|
15581963 |
2004 |
|
Cervical Intraepithelial Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Statistical analysis between the groups of cases with cervical intraepithelial neoplasia or invasive cervical cancer and the control group did not reveal any statistically significant difference in the frequency of the MTHFR C677T polymorphism.
|
12618332 |
2003 |
|
Cervical Intraepithelial Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A multiethnic case-control study was used to examine the association of dietary folate and MTHFR genotype with the odds ratios (ORs) for cervical dysplasia among women identified from several clinics on Oahu, Hawaii, between 1992 and 1996.
|
11751445 |
2001 |
|
Cervical Intraepithelial Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results suggested a significantly increased CIN risk with an alanine to valine substitution at amino acid 223 of MTHFR with an odds ratio of 2.9 (95% confidence interval: 1.2-7.9, p = 0.02).
|
10928104 |
2000 |